Uterine junctional zone contractions during assisted reproduction cycles.
Uterine junctional zone contractions during assisted reproduction cycles.
复制标题
辅助生殖周期期间子宫交界区收缩。
DOI：
10.1093/humupd/4.4.440
复制
发表时间：
1998
影响因子：
13.3
通讯作者：
S. Maguiness
中科院分区：
文献类型：
--
作者：
P. Lesny;S. Killick;R. Tetlow;J. Robinson;S. Maguiness
本研究旨在评估暴露于长期卵巢刺激方案的卵母细胞供体在体外受精（IVF）和胚胎移植周期中的接合区收缩（JZ）。采用实时阴道超声和先进的视听及计算机技术评价子宫收缩方式、频率和速度。下调时，未观察到JZ收缩。超排卵7天后，所有患者均出现宫颈-宫颈、宫颈-宫颈和随机收缩。人绒毛膜促性腺激素注射时，宫颈基底波占主导地位。但在取卵当天活性最强。此时相对波比例增加，基底-颈波消失。取卵时的波频和波速最高，分别为4.29+/-0.68波/min和2.73+/-0.54 mm/s。所有患者在取卵后第2、3、4天均有一定的JZ活性，但有规律的波状收缩力逐渐减弱，在取卵后第4天仅出现单一的随机运动。总之，与自然周期的观察结果相比，整个试管婴儿周期的JZ活性更为夸张，但遵循类似的模式。这一事实可能可以用激素水平的巨大差异来解释。较高的JZ活性和相应的子宫内膜流动性增加可能损害其接受性并影响着床。
This study was designed to assess junctional zone contractions (JZ) during cycles of in-vitro fertilization (IVF) and embryo transfer in oocyte donors exposed to a long protocol regime for ovarian stimulation. Real-time transvaginal ultrasound and advanced audio-visual and computer technology were used to evaluate the contraction pattern, frequency and velocity. At the time of down-regulation JZ contractions were not observed. After 7 days of superovulation all patients displayed cervico-fundal, fundo-cervical and random contractions. Cervico-fundal waves dominated the picture at the time of human chorionic gonadotrophin injection. However, the activity was strongest on the day of oocyte retrieval. At that time the percentage of opposing waves increased and fundo-cervical waves disappeared. The highest wave frequency and velocity (4.29+/-0.68 waves/min and 2.73+/-0.54 mm/s respectively) were observed at the time of oocyte retrieval. All patients had some JZ activity on days 2, 3 and 4 after oocyte retrieval but regular wave-like contractility gradually decreased and only single random movements were seen on day 4 after oocyte retrieval. In conclusion, JZ activity throughout the IVF cycle is more exaggerated when compared to the results reported from observations of the natural cycle but follows a similar pattern. This fact can probably be explained by the vastly different hormone levels. Higher JZ activity and correspondingly increased mobility of the endometrium may impair its receptivity and affect implantation.