Positron emission tomography analysis of the analgesic effects of acupuncture in rhesus monkeys
Positron emission tomography analysis of the analgesic effects of acupuncture in rhesus monkeys
复制标题
DOI：
10.1142/s0192415x06004296
复制
发表时间：
2006-01-01
影响因子：
5.7
通讯作者：
Ishida, Torao
中科院分区：
文献类型：
--
作者：
Maenaka, Toshihiro;Tano, Kaori;Ishida, Torao
本研究的目的是研究针刺镇痛是否能抑制疼痛引起的脑活动。我们使用正电子发射断层扫描（PET）研究了三只雄性恒河猴（4岁）特定脑区域疼痛诱导的神经元激活的抑制，其中区域脑血流量（rCBF）的变化作为神经元激活的指标进行了检测。在47摄氏度的水中加热猴子的尾巴，与在37摄氏度的水中加热猴子的尾巴相比，丘脑、岛和前扣带皮层等大脑区域被激活。这些激活被电针（EA）抑制，在右侧ST36（胫骨前上部肌肉）和右侧LI4（第一和第二掌骨之间的手掌后部）的频率有2个4 HZ/60 HZ的变化。同时，通过延长45 ~ 50℃热水的尾戒断潜伏期，证实了针刺镇痛作用。这些脑区与先前研究报道的疼痛相关脑区相对应。综上所述，我们能够在中枢神经系统中可视化针刺镇痛。我们还检测了针灸激活或不激活的大脑区域。在47℃的水中对针灸刺激的反应区域与在37℃的水中不同。我们认为，这种对针灸反应的差异可能支持针灸对疼痛或其他疾病患者临床疗效的差异。
The purpose of this study was to examine whether pain-induced brain activation was suppressed by acupuncture analgesia. We investigated the suppression of the pain-induced neuronal activation in specific brain areas of three male rhesus monkeys (aged four years old) using positron emission tomography (PET), in which changes in the regional cerebral blood flow (rCBF) were examined as an index of the neuronal activation. The brain areas such as the thalamus, insula and anterior cingulate cortex were activated by heating the tail of monkeys in 47 degrees C water compared to the heating at 37 degrees C. Those activations were suppressed by electroacupuncture (EA) with a 2 see alteration of the frequency of 4 HZ/60 Hz at the right ST36 (the upper anterior tibial muscle) and the right LI4 (the back palm between the first and second metacarpal) acupoints. Meanwhile, this EA analgesic effect was confirmed by prolonging the tail withdrawal latencies from hot water in the temperature range from 45 to 50 degrees C. These brain areas were corresponded to the pain-related areas as reported in previous studies, In conclusion, we were able to visualize the acupuncture analgesia in the CNS. We also detected the brain areas activated or inactivated by acupuncture. The areas that responded to acupuncture stimulation at 47 degrees C water were different from the regions at 37 degrees C. We consider that this difference in the response to acupuncture may support the variation of the clinical efficacy of acupuncture in patients bearing pain or other disorders.