Association between homocysteine levels and calcific aortic valve disease: a systematic review and meta-analysis.
Association between homocysteine levels and calcific aortic valve disease: a systematic review and meta-analysis.
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同型半胱氨酸水平与钙化性主动脉瓣疾病之间的关联：系统评价和荟萃分析
DOI：
10.18632/oncotarget.23938
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发表时间：
2018-02-02
期刊：
影响因子：
--
通讯作者：
Zeng Q
中科院分区：
文献类型：
--
作者：
Wu G;Xian J;Yang X;Li J;Liu J;Dong W;Su S;Li J;Tu Y;Peng J;Xu D;Zeng Q
关于同型半胱氨酸（Hcy）水平与钙化性主动脉瓣疾病（CAVD）之间的关系，以往的研究报道了不一致的结果。我们通过系统回顾和荟萃分析，研究了冠心病患者和对照组之间Hcy水平的相关性。我们对2017年3月底之前在PubMed、Embase、Web of Science、科克伦对照试验中心和中国生物医学文献数据库中发表的研究进行了系统检索。评价CAVD患者和对照组血浆Hcy水平的合格研究由两名独立研究者确定。使用随机效应模型估计标准化均值差（SMD）和相应的95%置信区间（95% CI）。纳入了10项研究，涉及6349名受试者。合并分析显示，与对照组相比，CAVD患者的Hcy水平显著升高（合并SMD：0.57，95%CI：0.36-0.79）。这种升高在美国和亚洲人群中比在土耳其人群中更明显。此外，轻中度CAVD和重度CAVD患者的Hcy水平显著升高。我们的研究结果表明，CAVD与Hcy水平升高有关。
Previous studies have reported inconsistent results regarding the association between homocysteine (Hcy) levels and calcific aortic valve disease (CAVD). We investigate the association between Hcy levels in patients with CAVD and controls by conducting a systematic review and meta-analysis. We conducted a systematic search of studies published prior to the end of March 2017 in the PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials and the Chinese Biomedical Literature databases. Eligible studies evaluating plasma Hcy levels in CAVD patients and controls were identified by two independent investigators. Standardized mean difference (SMD) and the corresponding 95% confidence intervals (95% CIs) were estimated using the random-effects model. Ten studies involving 6349 participants were included. Pooled analysis demonstrated that Hcy levels were significantly elevated in patients with CAVD compared with controls (pooled SMD: 0.57, 95% CI: 0.36–0.79). This elevation was more obvious in American and Asian populations than in Turkish populations. Furthermore, Hcy levels were significantly elevated in patients with mild-to-moderate CAVD and severe CAVD. Our results demonstrate that CAVD is associated with elevated Hcy levels.