Cyclical fate restriction: a new view of neural crest cell fate specification
Cyclical fate restriction: a new view of neural crest cell fate specification
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DOI：
10.1242/dev.176057
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发表时间：
2021-11-01
期刊：
影响因子：
4.6
通讯作者：
Rocco, Andrea
中科院分区：
文献类型：
--
作者：
Kelsh, Robert N.;Sosa, Karen Camargo;Rocco, Andrea
神经嵴细胞在发育中至关重要，尤其是因为它们具有显着的多能性。早期的发现激发了关于完全多能神经嵴细胞的命运规范和承诺如何发生的两种假设，即渐进命运限制（PFR）和直接命运限制，不同之处在于是否涉及部分限制的中间体。最初，尽管 PFR 受到青睐，但他们仍不可调和。然而，对斑马鱼色素细胞发育的 PFR 假设的测试驳斥了这一观点。我们提出了一种新颖的“周期性命运限制”假说，该假说基于转录状态的更动态的观点，协调了支撑传统假说的实验证据。
Neural crest cells are crucial in development, not least because of their remarkable multipotency. Early findings stimulated two hypotheses for how fate specification and commitment from fully multipotent neural crest cells might occur, progressive fate restriction (PFR) and direct fate restriction, differing in whether partially restricted intermediates were involved. Initially hotly debated, they remain unreconciled, although PFR has become favoured. However, testing of a PFR hypothesis of zebrafish pigment cell development refutes this view. We propose a novel 'cyclical fate restriction' hypothesis, based upon a more dynamic view of transcriptional states, reconciling the experimental evidence underpinning the traditional hypotheses.