Controlling the rate of coiled coil driven membrane fusion
Controlling the rate of coiled coil driven membrane fusion
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DOI：
10.1039/c3cc38926j
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发表时间：
2013-01-01
影响因子：
4.9
通讯作者：
Kros, Alexander
中科院分区：
文献类型：
--
作者：
Zheng, Tingting;Voskuhl, Jens;Kros, Alexander
已经设计了融合膜融合的互补脂化卷曲螺旋形成肽组。通过改变七肽重复序列的数目，研究了卷曲螺旋基序对脂质体融合速率的影响。我们发现互补肽的卷曲螺旋稳定性增加转化为脂质体的膜融合速率增加。
Sets of complementary lipidated coiled-coil forming peptides that fuse membrane fusion have been designed. The influence of the coiled-coil motif on the rate of liposome fusion was studied, by varying the number of heptad repeats. We found that an increased coiled-coil stability of complementary peptides translates into increased rates of membrane fusion of liposomes.