Influences from laryngeal afferents on expiratory bulbospinal neurons and motoneurons.
Influences from laryngeal afferents on expiratory bulbospinal neurons and motoneurons.
复制标题
喉传入对呼气球脊髓神经元和运动神经元的影响。
DOI：
10.1152/jappl.1988.64.4.1337
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Berger,AJ
中科院分区：
文献类型：
--
作者：
Jodkowski,JS;Berger,AJ
本研究的目的是分析喉传入兴奋对麻醉、迷走神经切断、麻痹、呼吸的猫呼吸模式的反射效应。我们同时记录了尾侧腹侧呼吸组(VRG)的膈神经、T10肋间内侧神经和单个球脊髓呼气神经元。通过电刺激喉上神经(SLN)或向喉内注入冷水来激活喉传入。这两种类型的刺激都能抑制膈神经的活动，促进肋间神经的活动，表明呼气努力。电刺激SLN时，46个延髓呼气细胞的活动受到抑制，其中13个细胞被完全抑制。在56个被测神经元中，44个神经元的平均放电频率(FFean)降低，8个神经元的平均放电频率增加，其余4个神经元的平均放电频率不变。讨论了SLN电刺激和注水后神经元反应不同的可能原因。我们的结论是，VRG的球脊髓呼气神经元不是刺激SLN产生的运动神经元呼气样反射活动的来源。在这个实验条件下，脊髓呼气运动神经元的其他尚未识别的输入被激活。
The purpose of this study is to analyze the reflex effects of laryngeal afferent activation on respiratory patterns in anesthetized, vagotomized, paralyzed, ventilated cats. We recorded simultaneously from the phrenic nerve, T10 internal intercostal nerve, and single bulbospinal expiratory neurons of the caudal ventral respiratory group (VRG). Laryngeal afferents were activated by electrical stimulation of the superior laryngeal nerve (SLN) or by cold-water infusion into the larynx. Both types of stimuli caused inhibition of phrenic activity and facilitation of internal intercostal nerve activity, indicating expiratory effort. The activity of 46 bulbospinal expiratory cells was depressed during SLN electrical stimulation, and 13 of them were completely inhibited. In 44 of 56 neurons tested, mean firing frequency (FFmean) was decreased in response to cold-water infusion and 8 others responded with increased FFmean; in the remaining 4 neurons, FFmean was unchanged. Possible reasons for different neuronal responses to SLN electrical stimulation and water infusion are discussed. We conclude that bulbospinal expiratory neurons of VRG were not the source of the reflex motoneuronal expiratory-like activity produced by SLN stimulation. Other, not yet identified inputs to spinal expiratory motoneurons are activated during this experimental condition.