DIRECT INPUT FROM AMYGDALA TO THALAMUS AND CEREBRAL-CORTEX
DIRECT INPUT FROM AMYGDALA TO THALAMUS AND CEREBRAL-CORTEX
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DOI：
10.1016/0006-8993(74)90309-6
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发表时间：
1974-01-01
期刊：
影响因子：
2.9
通讯作者：
PRICE, JL
中科院分区：
文献类型：
--
作者：
KRETTEK, JE;PRICE, JL
自艾略特·史密斯7时代以来，人们普遍认为丘脑是唯一直接投射到新皮质的皮层下结构，因此新皮质区域的结构和功能主要参考其丘脑连接来描述。 Nauta 14 提出了杏仁核复合体与额叶皮层部分之间的关系，但这被认为主要是通过杏仁核投射到丘脑背核来介导的。尽管有直接杏仁核皮质投射的报道S,6,13,16，但这些实验和其他关于杏仁核连接的实验的解释由于相邻结构的通道纤维可能中断以及小损伤后难以可靠地证明退化轴突等问题而变得复杂。为了避免这些问题，用于追踪轴突连接的放射自显影方法 4 被用于研究杏仁复合体的传出和传入连接。这些结果取自一系列 79 只大鼠和 10 只猫，其中 0.05-0.10/~1 的 2.5-5.0/zCi 氚化脯氨酸已被立体定向注射到每个杏仁核、丘脑内侧核和各种相关的皮质区域中。大鼠存活6小时至4天，猫存活7天后，给动物灌注10μl福尔马林盐水并进行放射自显影。为了定量杏仁核投射的某些方面，我们对丘脑和皮质区域进行了颗粒计数，手动或借助计算机显微镜系统进行自动颗粒计数17。在涉及外侧和基底外侧杏仁核2的大鼠实验中，在丘脑内侧核和大脑皮层的明确区域中发现了转运的放射性标记；在仅限于其他杏仁核的注射后，不会看到这些皮质和丘脑投射。大鼠的丘脑投射。大鼠的背核不能像高等动物那样容易细分，但即使在大鼠中，也可以识别中央的、富含纤维的部分以及中央部分两侧的内侧和外侧部分。向梨状皮层和嗅结节注射的实验表明，来自这些嗅觉结构的纤维终止于中央部分，证实了先前对这些投影的说明 9, 12。相反，
Since the time of Elliot Smith 7, it has been generally accepted that the thalamus is the only subcortical structure which projects directly to neocortex, and accordingly the structure and function of neocortical areas have been described mainly with reference to their thalamic connections. A relationship between the amygdaloid complex and portions of the frontal cortex has been proposed by Nauta 14, but this was considered to be mediated principally by way of an amygdaloid projection to the mediodorsal nucleus of the thalamus. Although there have been reports of direct amygdalocortical projectionsS, 6, 13, 16, the interpretation of these and other experiments on the connections of the amygdala have been complicated by such problems as the possible interruption of fibers of passage from adjacent structures and the difficulty of reliably demonstrating degenerating axons after small lesions. To avoid these problems the autoradiographic method for tracing axonal connections 4 is being used in a study of the efferent and afferent connections of the amygdaloid complex. These results are taken from a series of 79 rats and 10 cats in which 2.5-5.0/zCi of tritiated proline in 0.05-0.10/~ 1 have been stereotaxically injected into each of the amygdaloid nuclei, the mediodorsal thalamic nucleus, and various related cortical areas. Following survival times of 6 h to 4 days in the rat, and 7 days in the cat, the animals were perfused with 10~ formol-saline and processed for autoradiography. To quantitate certain aspects of the amygdaloid projections, grain counts have been made over areas of the thalamus and cortex either manually or with the aid of a computer-microscope system for automatic grain counting 17. In experiments in the rat with injections involving the lateral and basolateral amygdaloid nuclei 2, transported radioactive label is found in the mediodorsal thalamic nucleus, and in well-defined areas of the cerebral cortex; these cortical and thalamic projections are not seen following injections confined to the other amygdaloid nuclei. Thalamic projections in the rat. The mediodorsal nucleus cannot be subdivided in the rat as readily as it can in higher animals, but even in the rat it is possible to recognize a central, fiber-rich segment and medial and lateral segments which flank the central segment. Experiments with injections into the piriform cortex and olfactory tubercle show that fibers from these olfactory structures terminate in the central segment, confirming previous illustrations of these projections 9, 12. In contrast, in-