Preparation and biochemical evaluation of fluorenone-containing lipid analogs.
Preparation and biochemical evaluation of fluorenone-containing lipid analogs.
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含芴酮脂质类似物的制备和生化评价。
DOI：
10.1016/j.bmcl.2006.02.061
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Fielding,ChristopherJ
中科院分区：
文献类型：
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作者：
Spencer,ThomasA;Wang,Pingzhen;Popovici-Muller,JanetaV;Peltan,IthanD;Fielding,PhoebeE;Fielding,ChristopherJ
描述了脂肪酸类似物5和6以及含有芴酮基团的胆固醇（2）类似物7和8的合成，它们都是可光活化的和荧光的。作为生化研究工具的2的类似物的潜力已被证明的发现，7和8可以取代2在载脂蛋白A-I诱导的细胞外排的2和荧光是很容易看到的表面与8平衡的平滑肌细胞。
Syntheses are described of fatty acid analogs 5 and 6, and cholesterol (2) analogs 7 and 8 containing fluorenone groups, which are both photoactivable and fluorescent. The potential of the analogs of 2 as biochemical research tools has been demonstrated by the findings that 7 and 8 can replace 2 in apolipoprotein A-I-induced cellular efflux of 2 and that fluorescence is easily visible at the surface of smooth muscle cells equilibrated with 8.