Impaired parathyroid response to induced hypocalcemia in thalassemia major.
Impaired parathyroid response to induced hypocalcemia in thalassemia major.
复制标题
重型地中海贫血引起的低钙血症甲状旁腺反应受损。
DOI：
10.1016/s0022-3476(79)80653-8
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
Myron Genet
中科院分区：
文献类型：
--
作者：
Joseph M. Gertner;A. Broadus;Constantine S. Anast;Margaret Grey;Howard A. Pearson;Myron Genet
使用乙二胺四乙酸诱导的低钙血症作为甲状旁腺储备的激发试验，对 8 名血钙正常的重型地中海贫血患者（8 至 26 岁）和 5 名年轻成人对照受试者（22 至 35 岁）进行测试。静脉输注 EDTA 二钠 (50 mg/kg) 后，患者血清免疫反应性甲状旁腺激素升高 1.97±1.93 (SD) μLEq/ml，对照组升高 10.6±3.6 μLEq/ml (t=5.46，P<0.001)。甲状旁腺反应与通过血清铁蛋白或去铁胺诱导的尿铁排泄测量的总铁负荷之间没有关系。甲状旁腺储备受损在重型地中海贫血输血患者中很常见，可能是严重铁超负荷的标志。
Ethylene diamine tetra-acetic acid-induced hypocalcemia was used as a provocative test of parathyroid reserve in eight normocalcemic patients with thalassemia major (age 8 to 26 years) and five young adult control subjects (age 22 to 35). In response to an intravenous infusion of disodium EDTA (50 mg/kg), serum immunoreactive parathyroid hormone rose by 1.97±1.93 (SD) μlEq/ml in the patients, controls showing a rise of 10.6±3.6 μlEq/ml (t=5.46,P<0.001). There was no relationship between parathyroid response and total iron burden as measured by serum ferritin- or desferrioxamine-induced urinary iron excretion. Impairment of parathyroid reserve is common in transfused patients with thalassemia major and may serve as a marker of significant iron overload.