Chronic ingestion of ethanol increases the number of Ca2+ channels of hippocampal neurons of long-sleep but not short-sleep mice.
Chronic ingestion of ethanol increases the number of Ca2+ channels of hippocampal neurons of long-sleep but not short-sleep mice.
复制标题
长期摄入乙醇会增加长睡眠小鼠海马神经元的 Ca2 通道数量，但不会增加短睡眠小鼠的海马神经元 Ca2 通道数量。
DOI：
10.1016/0006-8993(93)90044-n
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发表时间：
1993
期刊：
影响因子：
2.9
通讯作者：
McArdle,JJ
中科院分区：
文献类型：
--
作者：
Huang,GJ;McArdle,JJ
比较正常小鼠和耐乙醇长睡眠和短睡眠小鼠海马神经元的全细胞和单通道 Ca2+ 电流。这些电流的特性对于正常 LS 和 SS 小鼠来说是相同的。相反，对于从长期摄入乙醇的 LS 小鼠中分离出的神经元，全细胞 Ca2+ 电流的峰值幅度显着增加，而 SS 小鼠则没有。由于单通道事件的功能特性发生了变化，这些数据表明，长期摄入乙醇会导致 LS 小鼠海马神经元膜中功能性 Ca2+ 通道数量的增加。
Whole cell and single channel Ca2+currents were compared for hippocampal neurons of normal and ethanol-tolerant long-sleep and short-sleep mice. The properties of these currents were equivalent for normal LS and SS mice. In contrast, the peak amplitude of the whole cell Ca2+current increased significantly for neurons isolated from LS but not SS mice chronically ingesting ethanol. Since there were bo changes in the functional properties of single channel events, these data indicate that chronic ingestion of ethanol causes an increase in the number of functional Ca2+channels in the membrane of hippocampal neurons of LS mice.