Preparation of Granulocyte‐Poor Red Blood Cells by Microaggregate Filtration
Preparation of Granulocyte‐Poor Red Blood Cells by Microaggregate Filtration
复制标题
通过微聚集体过滤制备贫粒细胞红细胞
DOI：
10.1111/j.1423-0410.1980.tb01872.x
复制
发表时间：
1980
期刊：
影响因子：
2.7
通讯作者：
E. Dugan
中科院分区：
文献类型：
--
作者：
B. Wenz;K. Gurtlinger;A. O'Toole;E. Dugan
Abstract. A simple, effective method for removing granulocytes from stored blood is described. Microaggregate filtration removes approximately 95% of the granulocytes from blood which has been stored for 2 weeks, centrifuged and filtered. The mean number of remaining leukocytes is 8 ± 3.7 × 108/unit. The residual white cell population, which is composed almost entirely of lymphocytes, is substantially less than the average number of cells previously associated with febrile reactions. 45 patients were selected for the study. All had significant febrile transfusion reaction histories, and averaged one reaction for every 3.6 U of conventional red cell product transfused. Administration of 212 units of microaggregate filtered granulocyte poor red cells caused a 95% reduction in the incidence of fibrile reactions. The technique is inexpensive, easily incorporated into the routine of the clinical blood bank, and does not require ‘open‐system’ processing. These considerations make microaggregate filtration a logical first choice method for the preparation of granulocyte‐poor red blood cells.
