The effects of olanzapine treatment on brain regional glucose metabolism in neuroleptic-naive first-episode schizophrenic patients.
The effects of olanzapine treatment on brain regional glucose metabolism in neuroleptic-naive first-episode schizophrenic patients.
复制标题
奥氮平治疗对未使用抗精神病药的首发精神分裂症患者脑部区域葡萄糖代谢的影响。
DOI：
10.1002/hup.2558
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Sano A
中科院分区：
文献类型：
--
作者：
Yoshimuta H;Nakamura M;Kanda E;Fujita S;Takeuchi K;Fujimoto T;Nakabeppu Y;Akasaki Y;Sano A
目的当前研究使用[18F]氟脱氧葡萄糖正电子发射断层扫描分析检查了与奥氮平阳性反应相关的代谢变化，并确定了与未使用过抗精神病药的首发精神分裂症患者的治疗相关症状改善相关的大脑区域。综合症量表。使用统计非参数映射对数据进行分析。结果在治疗前，与健康对照相比，反应者的颞上回和小脑的代谢显着增加。治疗后，反应者左中央前回、左中央后回和左中央旁小叶的葡萄糖代谢显着增加，而左下丘脑的葡萄糖代谢显着下降。对与奥氮平治疗相关的阳性和阴性症状量表症状的分析表明，“怀疑/迫害”评分与右额上回的代谢变化呈正相关。结论这些发现为奥氮平对精神分裂症早期代谢影响的神经机制提供了证据。
ObjectiveThe current study examined metabolic alterations associated with a positive response to olanzapine and identified brain regions associated with treatment‐related improvement of symptoms in neuroleptic‐naive first‐episode schizophrenic patients using [18F]fluoro‐deoxy‐glucose positron emission tomography analysis.MethodsNeuroleptic‐naive first‐episode schizophrenic patients who showed good or poor clinical responses to olanzapine were assessed using the Positive and Negative Syndrome Scale. Data were analyzed using statistical nonparametric mapping.ResultsBefore treatment, responders showed significantly increased metabolism in the superior temporal gyrus and cerebellum compared with healthy controls. Glucose metabolism in responders was significantly increased after treatment in the left precentral gyrus, left postcentral gyrus, and left paracentral lobule, and significantly decreased in the left hypothalamus. An analysis of the Positive and Negative Syndrome Scale symptoms associated with olanzapine treatment revealed that “suspiciousness/persecution” scores were positively correlated with metabolic changes in the right superior frontal gyrus.ConclusionsThese findings provide evidence of the neural mechanisms underlying the effects of olanzapine on metabolism in the early stages of schizophrenia.