Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability study
Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability study
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DOI：
10.1007/s00774-009-0080-8
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发表时间：
2009-09-01
影响因子：
3.3
通讯作者：
Akune, Toru
中科院分区：
文献类型：
--
作者：
Yoshimura, Noriko;Muraki, Shigeyuki;Akune, Toru
肌肉骨骼疾病，特别是骨关节炎（OA）和骨质疏松症（OP），损害了老年人的日常生活活动（ADL）和生活质量（QOL）。虽然老龄化社会迫切需要这些疾病的预防战略，但关于这些疾病的流行病学数据很少。为了明确日本膝关节骨关节炎（KOA）、腰椎病（LS）和骨质疏松症（OP）的患病率，并估计患有这些疾病的人数，我们于2005年开始了一项大规模的基于人群的队列研究，题为骨关节炎/骨质疏松症与残疾（ROAD）的研究。本研究收集了来自城市、山区和沿海地区的三个队列的临床信息。Kellgren-Lawrence标准将KOA和LS的放射学定义为千分之一日元2的等级；OP是根据日本骨与矿物研究协会的标准定义的。共有3040名参与者根据年龄分为六组：每千分之一的货币符号39、40-49、50-59、60-69、70-79和每千分之一的日元符号80。各年龄组KOA的男性患病率分别为0.39、0.40 - 0.49、0.50 - 0.59、0.60 - 0.69、0.70 - 0.79和0.80岁，男性患病率分别为0.9.1、24.3、35.2、48.2和51.6%，同一年龄组的女性患病率分别为3.2、11.4、30.3、57.1、71.9和80.7%。从年龄组来看，男性的LS患病率分别为14.3%、45.5%、72.9、74.6、85.3和90.1%，女性的LS患病率分别为9.7、28.6%、41.7、55.4、75.1和78.2%。我们还获得了腰椎和股骨颈OP患病率的数据。在日本，KOA、LS、L2-L4和股骨颈OP患者的估计数量分别约为25,38,640和1100万。总之，我们估计了日本OA和OP的患病率，以及受这些疾病影响的人数。ROAD研究将阐明有关骨关节疾病决定因素的流行病学证据。
Musculoskeletal diseases, especially osteoarthritis (OA) and osteoporosis (OP), impair activities of daily life (ADL) and quality of life (QOL) in the elderly. Although preventive strategies for these diseases are urgently required in an aging society, epidemiological data on these diseases are scant. To clarify the prevalence of knee osteoarthritis (KOA), lumbar spondylosis (LS), and osteoporosis (OP) in Japan, and estimate the number of people with these diseases, we started a large-scale population-based cohort study entitled research on osteoarthritis/osteoporosis against disability (ROAD) in 2005. This study involved the collection of clinical information from three cohorts composed of participants located in urban, mountainous, and coastal areas. KOA and LS were radiographically defined as a grade of a parts per thousand yen2 by the Kellgren-Lawrence scale; OP was defined by the criteria of the Japanese Society for Bone and Mineral Research. The 3,040 participants in total were divided into six groups based on their age: a parts per thousand currency sign39, 40-49, 50-59, 60-69, 70-79, and a parts per thousand yen80 years. The prevalence of KOA in the age groups a parts per thousand currency sign39, 40-49, 50-59, 60-69, 70-79, and a parts per thousand yen80 years 0, 9.1, 24.3, 35.2, 48.2, and 51.6%, respectively, in men, and the prevalence in women of the same age groups was 3.2, 11.4, 30.3, 57.1, 71.9, and 80.7%, respectively. With respect to the age groups, the prevalence of LS was 14.3, 45.5, 72.9, 74.6, 85.3, and 90.1% in men, and 9.7, 28.6, 41.7, 55.4, 75.1, and 78.2% in women, respectively. Data of the prevalence of OP at the lumbar spine and femoral neck were also obtained. The estimated number of patients with KOA, LS, and L2-L4 and femoral neck OP in Japan was approximately 25, 38, 6.4, and 11 million, respectively. In summary, we estimated the prevalence of OA and OP, and the number of people affected with these diseases in Japan. The ROAD study will elucidate epidemiological evidence concerning determinants of bone and joint disease.