Human NK cells inhibit cytomegalovirus replication through a noncytolytic mechanism involving lymphotoxin-dependent induction of IFN-β
Human NK cells inhibit cytomegalovirus replication through a noncytolytic mechanism involving lymphotoxin-dependent induction of IFN-β
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DOI：
10.4049/jimmunol.175.11.7568
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发表时间：
2005-12-01
影响因子：
4.4
通讯作者：
Benedict, CA
中科院分区：
文献类型：
--
作者：
Iversen, AC;Norris, PS;Benedict, CA
NK细胞通过穿孔素依赖性细胞溶解在宿主防御β-疱疹病毒CMV中发挥关键作用。在这项研究中，我们表明，人NK细胞也可以控制人巨细胞病毒（HCMV）感染的非细胞溶解机制，涉及在病毒感染的细胞中诱导IFN-β。IL-2激活的原代NK细胞和IL-2依赖的NK细胞系（NK-92）在非常低的E：T细胞比例下都表现出有效的非细胞溶解性抗HCMV活性（
NK cells play a key role in host defense against the beta-herpesvirus CMV through perforin-dependent cytolysis. In this study, we show that human NK cells can also control human CMV (HCMV) infection by a noncytolytic mechanism involving induction of IFN-beta in the virus-infected cell. Both IL-2-activated primary NK cells and an IL-2-dependent NK cell line (NK-92) exhibited potent, noncytolytic anti-HCMV activity at very low E:T cell ratios (