Cleavage-stage or blastocyst transfer: what are the benefits and harms?
Cleavage-stage or blastocyst transfer: what are the benefits and harms?
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DOI：
10.1016/j.fertnstert.2016.06.029
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发表时间：
2016-08-01
影响因子：
6.7
通讯作者：
Farquhar, Cynthia
中科院分区：
文献类型：
--
作者：
Glujovsky, Demian;Farquhar, Cynthia
ET是辅助生殖周期中的关键步骤。在过去的十年中，有一个增长的趋势，从卵裂期延长培养囊胚移植。也有一种趋势，即单次ET，并将辅助生殖周期的成功报告为使用新鲜和冷冻胚胎后的累积活产率。很少有证据表明，与新鲜卵裂期胚胎相比，新鲜囊胚移植与提高活产率有关。然而，在少数报告新鲜和冷冻移植后累积妊娠率的研究中，没有发现显著差异。卵裂期移植与更多可用于冷冻的胚胎数量相关，囊胚移植与无胚胎移植的周期数量增加相关。需要进一步精心设计的研究来评估囊胚移植的结果，包括新鲜和冷冻移植后的累积活产率、活产时间、不同移植策略的成本以及围产期死亡率和围产期严重发病率。（C）2016年美国生殖医学学会。
ET is a critical step in an assisted reproduction cycle. Over the past decade there has been an increasing trend to extending culture from cleavage-stage to blastocyst transfer. There has also been a trend to single ET and reporting the success of an assisted reproductive cycle as a cumulative live-birth rate after using both fresh and frozen embryos. There is low evidence that fresh blastocyst transfer is associated with improved live-birth rates compared with fresh cleavage-stage embryos. However, in the few studies that report cumulative pregnancy rates after fresh and frozen transfers, no significant difference was found. Cleavage-stage transfer is associated with greater numbers of embryos available for freezing, and blastocyst transfer is associated with increased number of cycles with no embryos to transfer. Further well-designed studies are warranted to evaluate the outcomes for blastocyst transfer including cumulative live-birth rate after fresh and frozen transfers, time to live birth, costs of the different transfer strategies, and perinatal mortality and severe perinatal morbidity. (C)2016 by American Society for Reproductive Medicine.