The actin bundling protein Fascin is important for proper early development in Strongylocentrotus purpuratus embryos.
The actin bundling protein Fascin is important for proper early development in Strongylocentrotus purpuratus embryos.
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DOI：
10.17912/micropub.biology.000717
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发表时间：
2023
影响因子：
--
通讯作者：
Song, Jia L
中科院分区：
文献类型：
--
作者：
Testa, Michael D;Remsburg, Carolyn M;Song, Jia L
肌成束蛋白是一种保守的蛋白质，已被证明可以调节细胞骨架。它在早期发展中的作用尚不清楚。受精后，胚胎经历快速的细胞分裂，需要细胞骨架的精确调节来分离染色体。结果表明，Fascin主要分布于细胞皮质，在非分裂期卵裂球的核周区和分裂期卵裂球的有丝分裂纺锤体上富集。Fascin的功能丧失导致显著的发育延迟或停滞，表明Fascin对于适当的早期胚胎发育是重要的。
Fascin is a conserved protein that has been shown to modulate the cytoskeleton. Its role in early development remains unclear. After fertilization, embryos undergo rapid cell divisions, requiring the precise regulation of cytoskeleton to segregate chromosomes. Results indicate that Fascin is in the cell cortex, enriched in the perinuclear region of non-dividing blastomeres and on the mitotic spindle of dividing blastomeres of the early embryo. Loss-of-function of Fascin leads to a significant developmental delay or arrest, indicating that Fascin is important for proper early embryonic development.