A Physical Activity Intervention to Treat the Frailty Syndrome in Older Persons-Results From the LIFE-P Study
A Physical Activity Intervention to Treat the Frailty Syndrome in Older Persons-Results From the LIFE-P Study
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DOI：
10.1093/gerona/glu099
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发表时间：
2015-02-01
影响因子：
5.1
通讯作者：
Pahor, Marco
中科院分区：
文献类型：
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作者：
Cesari, Matteo;Vellas, Bruno;Pahor, Marco
背景。虚弱综合症是一种公认的残疾风险状况。本研究的目的是探讨身体活动（PA）干预是否可以降低社区居住的有残疾风险的老年人的患病率和虚弱的严重程度。来自生活方式干预和老年人独立性试点的探索性分析，这是一项随机对照试验，招募了424名生活方式久坐且有行动障碍风险的社区居民（平均年龄=76.8岁）。参与者被随机分为为期12个月的PA干预组和成功的老年教育组。在基线、6个月和12个月时测量虚弱表型（即以下定义标准中的>= 3：非自愿体重减轻、疲劳、久坐行为、步态速度慢、握力差）。进行了重复测量广义线性模型。PA干预组12个月时的衰弱患病率（10.0%，95%可信区间= 6.5%,15.1%）与成功衰老组（19.1%，95%可信区间= 13.9%,15.6%）比较，差异有统计学意义（p= 0.01）。在随访中，与成功的衰老参与者相比，PA组中年轻受试者、黑人、虚弱参与者和多病参与者的虚弱标准的平均数量明显减少。在衰弱标准中，久坐行为是受干预影响最大的一项。定期PA可以减少虚弱，特别是对于那些残疾风险较高的人。未来的研究应着眼于测试多领域干预对脆弱性可能产生的益处。
Background. The frailty syndrome is as a well-established condition of risk for disability. Aim of the study is to explore whether a physical activity (PA) intervention can reduce prevalence and severity of frailty in a community-dwelling elders at risk of disability.Methods. Exploratory analyses from the Lifestyle Interventions and Independence for Elders pilot, a randomized controlled trial enrolling 424 community-dwelling persons (mean age=76.8 years) with sedentary lifestyle and at risk of mobility disability. Participants were randomized to a 12-month PA intervention versus a successful aging education group. The frailty phenotype (ie, >= 3 of the following defining criteria: involuntary weight loss, exhaustion, sedentary behavior, slow gait speed, poor handgrip strength) was measured at baseline, 6 months, and 12 months. Repeated measures generalized linear models were conducted.Results. A significant (p=.01) difference in frailty prevalence was observed at 12 months in the PA intervention group (10.0%; 95% confidence interval = 6.5%, 15.1%), relative to the successful aging group (19.1%; 95% confidence interval = 13.9%, 15.6%). Over follow-up, in comparison to successful aging participants, the mean number of frailty criteria in the PA group was notably reduced for younger subjects, blacks, participants with frailty, and those with multimorbidity. Among the frailty criteria, the sedentary behavior was the one most affected by the intervention.Conclusions. Regular PA may reduce frailty, especially in individuals at higher risk of disability. Future studies should be aimed at testing the possible benefits produced by multidomain interventions on frailty.