Involvement of Glutamate in Rest-Stimulus Interaction Between Perigenual and Supragenual Anterior Cingulate Cortex: A Combined fMRI-MRS Study
Involvement of Glutamate in Rest-Stimulus Interaction Between Perigenual and Supragenual Anterior Cingulate Cortex: A Combined fMRI-MRS Study
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DOI：
10.1002/hbm.21179
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发表时间：
2011-12-01
影响因子：
4.8
通讯作者：
Northoff, Georg
中科院分区：
文献类型：
--
作者：
Duncan, Niall W.;Enzi, Bjoern;Northoff, Georg
大脑在休息时表现出高度的活动。这项活动的重要性日益受到关注。然而，目前，这种活动和刺激诱导的活动之间的相互作用还没有得到很好的定义。因此，在一个简单的任务，任务负（膝周前扣带皮层，pgACC）和任务正（膝上前扣带皮层，sgACC）区域之间的相互作用进行了研究，使用功能磁共振成像和MRS相结合。负BOLD反应的pgACC被发现显示出单向有效的连接与任务引起的正BOLD反应的sgACC。这种连接性被证明与pgACC中的谷氨酸水平特别相关。这些结果表明，从静息态和静息态谷氨酸水平的任务负区域（pgACC），和任务诱导的活动在任务正区域（sgACC）之间的相互作用失活。这提供了对神经元和生化机制的深入了解，通过这些机制，大脑的静息状态活动可能会影响随后的刺激诱导的活动。《脑地图》32：2172-2182，2011年。(C)2011 Wiley Periodicals，Inc.
The brain shows a high degree of activity at rest. The significance of this activity has come increasingly into focus. At present, however, the interaction between this activity and stimulus-induced activity is not well defined. The interaction between a task-negative (perigenual anterior cingulate cortex, pgACC) and task-positive (supragenual anterior cingulate cortex, sgACC) region during a simple task was thus investigated using a combination of fMRI and MRS. Negative BOLD responses in the pgACC were found to show a unidirectional effective connectivity with task-induced positive BOLD responses in the sgACC. This connectivity was shown to be related specifically with glutamate levels in the pgACC. These results demonstrate an interaction between deactivation from resting-state and resting-state glutamate levels in a task-negative region (pgACC), and task-induced activity in a task-positive region (sgACC). This provides insight into the neuronal and biochemical mechanisms by means of which the resting state activity of the brain potentially impacts upon subsequent stimulus-induced activity. Hum Brain Mapp 32:2172-2182, 2011. (C) 2011 Wiley Periodicals, Inc.