Non-HDL cholesterol as a predictor of cardiovascular disease in type 2 diabetes - The Strong Heart Study
Non-HDL cholesterol as a predictor of cardiovascular disease in type 2 diabetes - The Strong Heart Study
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DOI：
10.2337/diacare.26.1.16
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发表时间：
2003-01-01
期刊：
影响因子：
16.2
通讯作者：
Howard, BV
中科院分区：
文献类型：
--
作者：
Lu, WQ;Resnick, HE;Howard, BV
目的-为了确定是否非高密度脂蛋白胆固醇，总胆固醇减去高密度脂蛋白胆固醇的措施，是糖尿病患者心血管疾病的预测因素。研究设计和方法-强心研究，心血管疾病及其危险因素的人口为基础的研究，在13个美国印第安社区在三个地理区域在美国的基线检查，1989年7月和1992年1月之间进行，包括个人面谈、身体检查和实验室检查。在4，549名年龄在45 - 74岁的女性和男性中，2，108人患有糖尿病，但基线时没有CVD。致命性和非致命性心血管疾病的数据收集在随访期间至1998年12月31日（平均9年）。结果-多变量分析表明，非高密度脂蛋白胆固醇是一个强有力的预测心血管疾病的男性和女性糖尿病患者，特别是冠心病事件的指示。男性和女性糖尿病患者中非HDL胆固醇最高三分位数的风险比（分别为2.23和1.80）高于男性和女性中单独的LDL胆固醇或甘油三酯的风险比，也高于女性中总胆固醇/HDL胆固醇的比值。非高密度脂蛋白胆固醇预测心血管疾病的效用扩展了广泛的甘油三酯concentrations.CONCLUSIONS -这项研究表明，非高密度脂蛋白胆固醇指数可能特别有用的糖尿病患者的心血管疾病风险预测。
OBJECTIVE - To determine whether non-HDL cholesterol, a measure of total cholesterol minus HDL cholesterol, is a predictor of CVD in patients with diabetes.RESEARCH DESIGN AND METHODS - The Strong Heart Study, a population-based study of CVD and its risk factors in 13 American Indian communities in three geographic areas in the U.S. The baseline examination, conducted between July 1989 and January 1992, consisted of a personal interview, a physical examination, and laboratory tests. Of the 4,549 women and men aged 45 - 74 years participating in the study, 2,108 had diabetes but no CVD at baseline. Data on fatal and nonfatal CVD were collected during the follow-up period through 31 December 1998 (average 9 years).RESULTS - Multivariable analyses indicated that non-HDL cholesterol is a strong predictor of CVD in men and women with diabetes and is particularly indicative of coronary events. Hazard ratios for the highest tertile of non-HDL cholesterol in men and women with diabetes (2.23 and 1.80, respectively) were higher than those for either LDL cholesterol or triglycerides alone in both men and women and were higher than the ratio of total/HDL cholesterol in women. The utility of non-HDL cholesterol in predicting CVD extended over a wide range of triglyceride concentrations.CONCLUSIONS - This study suggests that non-HDL cholesterol index maybe particularly useful in predicting CVD risk in patients with diabetes.