Archaeal Chromatin Organization
Archaeal Chromatin Organization
复制标题
DOI：
10.1007/978-90-481-3473-1_10
复制
发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
White, Malcolm F.
中科院分区：
文献类型：
--
作者：
Bell, Stephen D.;White, Malcolm F.
在光学显微镜下，古菌与细菌相似，因为它们是小的、通常是单细胞的生物体，没有明显的亚细胞组织。它们的基因组(大小从0.5到类似6Mb)是在浓缩的类核结构中发现的，而不是在细胞核内，因此古生物可以广泛地归类为“原核生物”。与细菌一样，各种复杂的蛋白质似乎在压缩古生菌类核结构方面发挥了作用。然而，尽管细菌和古生菌的亚细胞特征在组织上有相似之处，但古生菌的类核相关蛋白与形成真核细胞染色质的蛋白质有有趣的相似之处。这些相似之处在两个方面都得到了体现。在物理水平上，以一些真核和古生物历史蛋白的结构正交学的形式，在概念水平上，在调控古生代染色质蛋白的DNA结合模式中，共价修饰的作用。
In the light microscope, archaea resemble bacteria, in that they are small, generally single-celled organisms devoid of overt subcellular organization. Their genomes (which range in size from 0.5 to similar to 6 Mb) are found in condensed nucleoid structures, rather than within nuclei and so the archaea can be broadly classified as "prokaryotes". As in bacteria, a complex variety of proteins appear to play roles in compacting archaeal nucleoid structures. However, despite the organisational similarity between bacterial and archaeal subcellular features, archaeal nucleoid-associated proteins have intriguing parallels with the proteins that shape eukaryotic chromatin. These similarities manifest themselves both at the. physical level, in the form of the structural orthology of some eukaryotic and archaeal historic proteins, and at the conceptual level, in the role of covalent modifications in modulating the DNA binding mode of archaeal chromatin proteins.