SKELETAL-MUSCLE CAPILLARY DENSITY AND FIBER TYPE ARE POSSIBLE DETERMINANTS OF INVIVO INSULIN RESISTANCE IN MAN
SKELETAL-MUSCLE CAPILLARY DENSITY AND FIBER TYPE ARE POSSIBLE DETERMINANTS OF INVIVO INSULIN RESISTANCE IN MAN
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DOI：
10.1172/jci113088
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发表时间：
1987-08-01
影响因子：
15.9
通讯作者：
BOGARDUS, C
中科院分区：
文献类型：
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作者：
LILLIOJA, S;YOUNG, AA;BOGARDUS, C
我们比较了23名高加索人和41名PIMA印度非糖尿病男性的股外侧肌的毛细血管密度和肌纤维类型与正常血糖钳(M值)测定的体内胰岛素作用。M值与毛细血管密度显著相关(r=0.63，P<0.01)。0.0001)、I型纤维百分比(r=0.29P<；0.02)和2B型纤维百分比(r=-0.38P<；0.003)。空腹血糖和胰岛素浓度与毛细血管密度呈显著负相关(r=-0.46，P<0.01)。0.0001；r=-0.47P。分别为0.0001)。腰围/股围比值与1型纤维百分率呈正相关(r=-0.39；P<；0.002)。这些结果表明，从毛细血管到肌肉细胞的扩散距离或与之相关的某些生化变化，以及纤维类型，可能在决定体内胰岛素的作用方面发挥作用。肌肉纤维类型与身体脂肪分布的关联可能表明，中心性肥胖只是更普遍的代谢综合征的一个方面。这些数据可能至少部分解释了与肥胖相关的胰岛素抵抗，以及肥胖者胰岛素作用动力学的改变。
We have compared the capillary density and muscle fiber type of musculus vastus lateralis with in vivo insulin action determined by the euglycemic clamp (M value) in 23 Caucasians and 41 Pima Indian nondiabetic men. M value was significantly correlated with capillary density (r = 0.63; P .ltoreq. 0.0001), percent type I fibers (r = 0.29; P < 0.02), and percent type 2B fibers (r = -0.38; P < 0.003). Fasting plasma glucose and insulin concentrations were significantly negatively correlated with capillary density (r = -0.46, P .ltoreq. 0.0001; r = -0.47, P .ltoreq. 0.0001, respectively). Waist circumference/thigh circumference ratio was correlated with percent type 1 fibers (r = -0.39; P < 0.002). These results suggest that diffusion distance from capillary to muscle cells or some associated biochemical change, and fiber type, could play a role in determining in vivo insulin action. The association of muscle fiber type with body fat distribution may indicate that central obesity is only one aspect of a more generalized metabolic syndrome. The data may provide at least a partial explanation for the insulin resistance associated with obesity and for the altered kinetics of insulin action in the obese.