Design of a small animal PET imaging system with 1 microliter volume resolution
Design of a small animal PET imaging system with 1 microliter volume resolution
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DOI：
10.1109/tns.2004.829738
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发表时间：
2004-06-01
影响因子：
1.8
通讯作者：
Hutchins, GD
中科院分区：
文献类型：
--
作者：
Rouze, NC;Schmand, M;Hutchins, GD
介绍了一种用于小动物PET成像的新型扫描仪的设计。目标是在一个适合全身老鼠成像的体积内，在三个垂直方向中的每一个方向上达到1 mm的半高宽分辨率，直径大约40 mm x长80 mm。同时，该设计应实现来自位于扫描仪中心的点源的所有衰变的5%以上的灵敏度。扫描仪使用12个平面探测器组，以160 mm直径的环安装在旋转龙门上。每个探测器组由48×108个20 mm长的LSO晶体阵列组成，阵列间距为0.87 mm。每家银行使用两个滨松H8500大面积、多阳极光电倍增管进行荧光检测。探测器组被分成两组，相应的响应线偏移阵列间距的四分之一以增加采样密度。使用原型晶体阵列的测试表明，可以分辨单个晶体。已经进行了仿真，以评估完整扫描仪的预期性能。对于F-18点光源，对于整个目标视场(FOV)中的源位置，径向、切向和轴向的FWHM分辨率小于1 mm。同时，对于位于视场中心的点源，探测器灵敏度大于所有衰减的7%，还给出了使用不同的PET同位素进行模拟以研究正电子范围的影响的结果，以及对于包含热点的体模的结果，以评估扩展对象的扫描性能。
The design of a new scanner for use in small animal PET imaging is described. The goal is to achieve 1 mm FWHM resolution in each of three orthogonal directions throughout a volume suitable for whole body mouse imaging, roughly 40 mm diameter x 80 mm long. Simultaneously, the design should achieve a sensitivity of greater than 5% of all decays from a point source located at the center of the scanner.The scanner uses 12, plane detector banks mounted in a 160 mm diameter ring on a rotating gantry. Each detector bank consists of a 48 x 108 array of 20 mm long LSO crystals with an array pitch of 0.87 mm. Each bank uses two Hamamatsu H8500 large-area, multi-anode photomultiplier tubes for fluorescence detection. The detector banks are divided into two sets with the respective lines of response offset by one quarter of the array pitch to give increased sampling density.Tests using a prototype crystal array demonstrate that individual crystals can be resolved. Simulations have been performed to evaluate the performance expected in the complete scanner. With F-18 point sources, the FWHM resolutions in the radial, tangential, and axial directions are less than 1 mm for source positions throughout the desired field of view (FOV). Simultaneously, the detector sensitivity is greater than 7% of all decays for a point source located at the center of the FOV Results are also presented for simulations using different PET isotopes to investigate the effect of positron range, and for a phantom containing hot spots added to a uniform background to evaluate the scanner performance for an extended object.