Severe soft tissue infection caused by a non-beta-hemolytic Streptococcus pyogenes strain harboring a premature stop mutation in the sagC gene.
Severe soft tissue infection caused by a non-beta-hemolytic Streptococcus pyogenes strain harboring a premature stop mutation in the sagC gene.
复制标题
由带有 sagC 基因过早停止突变的非 β 溶血性化脓性链球菌菌株引起的严重软组织感染。
DOI：
10.1128/jcm.00175-13
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发表时间：
2013
影响因子：
9.4
通讯作者：
vanderLinden,Mark
中科院分区：
文献类型：
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作者：
Jantsch,Jonathan;Gerlach,RomanG;Ensser,Armin;Dahesh,Samira;Popp,Isabel;Heeg,Christiane;Bleiziffer,Oliver;Merz,Thomas;Schulz,Theresia;Horch,RaymundE;Bogdan,Christian;Nizet,Victor;vanderLinden,Mark
我们从严重的软组织感染中恢复了一株非β-溶血性化脓性链球菌。在该分离株中，我们在链溶素S(SLS)生物合成操纵子的agC基因中检测到一个提前停止密码子。将全长sagC基因重新导入到我们的临床分离株中，恢复了β-溶血表型，表明点突变insagC导致了溶血活性的丧失。据我们所知，这是第一个证明严重软组织感染可以由缺乏功能的SagC的非β-溶血性化脓性链球菌引起的报告。
We recovered a non-beta-hemolytic Streptococcus pyogenes strain from a severe soft tissue infection. In this isolate, we detected a premature stop codon within thesagCgene of the streptolysin S (SLS) biosynthetic operon. Reintroduction of full-lengthsagCgene on a plasmid vector restored the beta-hemolytic phenotype to our clinical isolate, indicating that the point mutation insagCaccounted for loss of hemolytic activity. To the best of our knowledge, this is the first report to demonstrate that a severe soft tissue infection can be caused by a non-beta-hemolytic S. pyogenes strain lacking a functional SagC.