Central airway issues in bronchopulmonary dysplasia.
Central airway issues in bronchopulmonary dysplasia.
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DOI：
10.1002/ppul.25417
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发表时间：
2021-11
影响因子：
3.1
通讯作者：
Hysinger EB
中科院分区：
文献类型：
--
作者：
Hysinger EB
虽然对肺实质发育异常的关注非常大，并广泛努力通过“温和通气”和无创呼吸支持来减少支气管肺发育不良（BPD）新生儿的肺泡损伤，但对这类患者群体中央性气道疾病的影响考虑相对较少。在妊娠后半期，中央气道的结构和构象发生了显著变化，早产破坏了这一自然发育过程。成熟的停止导致气道更小，更柔顺，更容易变形，更容易受到损害。因此，患有BPD的新生儿容易出现中枢气道病理，特别是需要插管和正压通气的患者。中央气道疾病可分为动态气道阻塞和固定气道阻塞，导致早产儿慢性肺部疾病新生儿呼吸系统发病率增加。
While there is a very large focus on the abnormalities of parenchymal lung development and extensive efforts to minimize alveolar damage with “gentle ventilation” and non-invasive respiratory support for neonates with bronchopulmonary dysplasia (BPD), there is relatively little consideration for the implications of central airway disease in this patient population. There are significant changes in the structure and conformation of the central airway during the last half of gestation, and premature birth disrupts this natural developmental process. Arrest of maturation results in a smaller airway that is more compliant, easier to deform, and more susceptible to damage. Consequently, neonates with BPD are prone to developing central airway pathology, particularly for patients who require intubation and positive pressure ventilation. Central airway disease can be divided into dynamic and fixed airway obstruction and results in increased respiratory morbidity in neonates with chronic lung disease of prematurity.