Modulation of the Oxidative Stress and Lipid Peroxidation by Endocannabinoids and Their Lipid Analogues.
Modulation of the Oxidative Stress and Lipid Peroxidation by Endocannabinoids and Their Lipid Analogues.
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DOI：
10.3390/antiox7070093
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发表时间：
2018-07-18
期刊：
影响因子：
--
通讯作者：
Gaetani S
中科院分区：
文献类型：
--
作者：
Gallelli CA;Calcagnini S;Romano A;Koczwara JB;de Ceglia M;Dante D;Villani R;Giudetti AM;Cassano T;Gaetani S
越来越多的证据支持氧化应激在组织损伤发展中发挥的关键作用，从而导致多种病理，包括心血管、肾脏、神经精神和神经退行性疾病，所有这些疾病的特征都是氧化状态改变。活性氧和氮物质以及脂质过氧化衍生的活性醛，包括丙烯醛、丙二醛和4-羟基-2-壬烯醛等，是氧化还原依赖性过程中发生的细胞和组织损伤的主要原因。在这种情况下，内源性大麻素系统（ECS）和氧化还原稳态损伤之间的联系似乎是至关重要的。花生四烯酸和2-花生四烯酸甘油是最具特征的内源性大麻素，能够通过靶向1型和2型大麻素受体以及其他受体（如瞬时受体电位香草素1、过氧化物酶体增殖物激活受体α和孤儿G蛋白偶联受体18和55）来调节几种抗氧化酶的活性。此外，内源性大麻素脂质类似物N-酰基乙醇胺显示通过恢复细胞内氧化剂-抗氧化剂平衡来保护细胞损伤和死亡免受反应性类固醇诱导的氧化应激。在这篇综述中，我们将提供一个更好的理解的氧化应激和ECS之间的串扰触发的主要机制，还侧重于酶和非酶抗氧化剂作为清除剂的反应性醛和它们的有毒生物活性加合物。
Growing evidence supports the pivotal role played by oxidative stress in tissue injury development, thus resulting in several pathologies including cardiovascular, renal, neuropsychiatric, and neurodegenerative disorders, all characterized by an altered oxidative status. Reactive oxygen and nitrogen species and lipid peroxidation-derived reactive aldehydes including acrolein, malondialdehyde, and 4-hydroxy-2-nonenal, among others, are the main responsible for cellular and tissue damages occurring in redox-dependent processes. In this scenario, a link between the endocannabinoid system (ECS) and redox homeostasis impairment appears to be crucial. Anandamide and 2-arachidonoylglycerol, the best characterized endocannabinoids, are able to modulate the activity of several antioxidant enzymes through targeting the cannabinoid receptors type 1 and 2 as well as additional receptors such as the transient receptor potential vanilloid 1, the peroxisome proliferator-activated receptor alpha, and the orphan G protein-coupled receptors 18 and 55. Moreover, the endocannabinoids lipid analogues N-acylethanolamines showed to protect cell damage and death from reactive aldehydes-induced oxidative stress by restoring the intracellular oxidants-antioxidants balance. In this review, we will provide a better understanding of the main mechanisms triggered by the cross-talk between the oxidative stress and the ECS, focusing also on the enzymatic and non-enzymatic antioxidants as scavengers of reactive aldehydes and their toxic bioactive adducts.
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影响因子：
4.3
作者：
Bedse G;Di Domenico F;Serviddio G;Cassano T
通讯作者：
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影响因子：
4.8
作者：
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DOI：
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发表时间：
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影响因子：
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