Paired helical filament morphology varies with intracellular location in Alzheimer's disease brain
Paired helical filament morphology varies with intracellular location in Alzheimer's disease brain
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DOI：
10.1016/s0304-3940(97)00876-8
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发表时间：
1997-12-12
影响因子：
2.5
通讯作者：
Kidd, M
中科院分区：
文献类型：
--
作者：
Kurt, MA;Davies, DC;Kidd, M
成对螺旋丝 (PHF) 是阿尔茨海默病 (AD) 的标志性病理学之一。 PHF 出现在细胞内的三个位置，尽管迄今为止，尚不清楚所有 PHF 是否在结构上都是同质的。对 5 名临床和组织病理学诊断为 AD 的患者进行顶叶皮质活检，并进行电子显微镜检查。然后拍摄神经原纤维缠结 (NFT)、神经纤维丝 (NT) 和神经炎斑 (NP) 神经突中 PHF 的显微照片，并测量它们的尺寸。 NFT 中 PHF 的平均半周期、最大和最小宽度显着小于 NT 或 NP 神经突中的 PHF。 NT 中 PHF 的平均半周期和最大宽度与 NP 神经突中的相似。这些结果揭示了两种不同的 PHF 群体的存在，对它们之间关系的研究可能有助于揭示 AD 的发病机制。 (C) 1997 爱思唯尔科学爱尔兰有限公司
Paired helical filaments (PHFs) are one of the hallmark pathologies of Alzheimer's disease (AD). PHFs occur in three intracellular locations, although hitherto, it was not known whether all PHFs are structurally homogeneous. Parietal cortex biopsies were taken from five patients with a clinical and histopathological diagnosis of AD and processed for electron microscopy. Photomicrographs were then taken of PHFs in neurofibrillary tangles (NFTs), neuropil threads (NTs) and neuritic plaque (NP) neurites and their dimensions measured. The mean half period, maximum and minimum widths of PHFs in NFTs were significantly smaller than those in NTs or NP neurites. The mean half period and maximum width of PHFs in NTs were similar to those in NP neurites. These results reveal the presence of two distinct PHF populations and investigation of their relationship may shed light on the pathogenesis of AD. (C) 1997 Elsevier Science Ireland Ltd.