Recent Advances in Studies of Itai-itai Disease.
Recent Advances in Studies of Itai-itai Disease.
复制标题
痛痛病研究的最新进展。
DOI：
10.1248/jhs1956.43.317
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
K. Aoshima
中科院分区：
文献类型：
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作者：
K. Aoshima
本文综述了近年来主要从1980年以来对板-板病的研究。从1980年到1996年，51名患者被正式指定为患有IID。最后一名病人于1994年登记，他于1991年72岁时主诉骨痛。这一事实表明，即使在今天，仍有新的艾滋病病例发生。1979-1991年75例IID尸检中，45例（60%）出现骨软化的特征性松动带。在肋骨（356）、股骨（44）、尺骨（12）、耻骨支（9）和其他骨中发现大量Looser区。骨组织病理学最显著的特征是明显的类骨质积聚，伴有骨量减少。骨密度测定法评估的骨丢失与肾小管功能障碍的严重程度有关。IID的肾脏损害以肾小管间质性肾病为特征，并且肾皮质中肾小管的萎缩性改变的等级与肾脏重量的减少定量相关。通过长期观察血清肌酐评估的肾功能显示持续降低。贫血和低钙血症，发现在终末期的IID，密切相关的肾功能受损。广泛的测量重金属的器官来自IID的尸检病例显示显着较低的镉，锌，铜在肾脏的值，而显着较高的镉和锌的值被发现在肝脏，胰腺，甲状腺和其他器官相比，对照组。可以推断，IID患者的肾脏曾经有高浓度的Cd，这些Cd已被排泄到尿液中，与肾小管上皮的消融有关。在此基础上，对IID的发病机制进行了讨论。
The recent studies of Itai-itai disease (IID) which have been mainly conducted since 1980 is reviewed. Fifty-one patients were officially designated as having IID from 1980 to 1996. The latest patient registered in 1994 complained of having a bone pain at the age of 72 in 1991. This fact indicates the occurrence of new cases of IID even today. In 75 autopsy cases of IID (1979-1991), Looser zones, which are characteristic of osteomalacia, were observed in 45 (60%). A large number of Looser zones were found in the ribs (356), femur (44), ulna (12), pubic ramus (9) and other bones. The most conspicuous feature of bone histopathology was a marked osteoid accumulation accompanied by the reduction of a bone mass. Loss of bone evaluated by densitometry was related to the severity of renal tubular dysfunction. The renal lesion of IID is characterized by tubulointerstitial nephropathy, and the grade of atrophic changes in tubules in the renal cortex correlates quantitatively with a decrease in kidney weight. The renal function assessed by long-term observation of serum creatinine showed a sustained reduction. Anemia and hypocalcemia, found in the end-stage of IID, were closely associated with an impaired renal function. Extensive measurements of heavy metals in the organs derived from the autopsy cases of IID have shown significantly lower values of Cd, Zn, and Cu in the kindneys, whereas significantly higher values of Cd and Zn were found in the liver, pancreas, thyroid and other organs compared to the control group. It can be inferred that the kidneys of those with IID once had high concentrations of Cd which had been excreted into the urine, associated with the ablation of tubular epithelium. On the based of these findings, the pathogenesis of IID is discussed.