Sleep states alter activity of suprachiasmatic nucleus neurons
Sleep states alter activity of suprachiasmatic nucleus neurons
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DOI：
10.1038/nn1122
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发表时间：
2003-10-01
影响因子：
25
通讯作者：
Meijer, JH
中科院分区：
文献类型：
--
作者：
Deboer, T;Vansteensel, MJ;Meijer, JH
哺乳动物的睡眠和觉醒时间由睡眠稳态过程和视交叉上核（SCN）的昼夜节律钟控制，该昼夜节律钟具有节律产生的分子基础。通过将SCN电活动记录与同一动物（Wistar大鼠）的脑电图（EEG）记录相结合，我们发现，警觉状态的变化被SCN电生理活动的强烈变化所掩盖。在快速眼动（REM）睡眠期间，SCN中的神经元活动升高，而在非REM（NREM）睡眠期间，它降低。我们还进行了选择性睡眠剥夺实验，以证实SCN电活动的变化是由警觉状态的变化引起的。我们的研究结果表明，24小时的模式，由SCN的分子机制控制的电活动是从中枢神经系统的传入信息大大修改。
The timing of sleep and wakefulness in mammals is governed by a sleep homeostatic process and by the circadian clock of the suprachiasmatic nucleus (SCN), which has a molecular basis for rhythm generation. By combining SCN electrical activity recordings with electroencephalogram (EEG) recordings in the same animal (the Wistar rat), we discovered that changes in vigilance states are paralleled by strong changes in SCN electrophysiological activity. During rapid eye movement (REM) sleep, neuronal activity in the SCN was elevated, and during non-REM (NREM) sleep, it was lowered. We also carried out selective sleep deprivation experiments to confirm that changes in SCN electrical activity are caused by changes in vigilance state. Our results indicate that the 24-hour pattern in electrical activity that is controlled by the molecular machinery of the SCN is substantially modified by afferent information from the central nervous system.