Gold-Catalyzed Post-Ugi Ipso-Cyclization with Switchable Diastereoselectivity.
Gold-Catalyzed Post-Ugi Ipso-Cyclization with Switchable Diastereoselectivity.
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DOI：
10.1021/acs.joc.8b00953
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发表时间：
2018-07
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影响因子：
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通讯作者：
Anton A. Nechaev;K. Van Hecke;Manzoor Zaman;S. Kashtanov;L. Ungur;Olga P. Pereshivko;Vsevolod A. Peshkov;E. V. Van der Eycken
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文献类型：
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作者：
Anton A. Nechaev;K. Van Hecke;Manzoor Zaman;S. Kashtanov;L. Ungur;Olga P. Pereshivko;Vsevolod A. Peshkov;E. V. Van der Eycken
本文报道了一种金催化的Ugi异构环后环化反应，用于螺环吡咯-2-酮体系的非对映选择性合成。通过调节催化体系、溶剂和温度，可以选择性地得到两组非对映异构体。对这一过程的范围进行了评估，并提出了一个假定的机理模型。
A gold-catalyzed post-Ugi ipso-cyclization for the diastereoselective synthesis of spirocyclic pyrrol-2-one-dienone system is described. Tuning the catalytic system, solvent, and temperature allowed selectively attaining two sets of diastereoisomers. The scope of the process has been evaluated, and a putative mechanistic model was proposed.