Comparison of probiotic lactobacilli and bifidobacteria effects, immune responses and rotavirus vaccines and infection in different host species.
Comparison of probiotic lactobacilli and bifidobacteria effects, immune responses and rotavirus vaccines and infection in different host species.
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DOI：
10.1016/j.vetimm.2016.01.003
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发表时间：
2016-04
影响因子：
1.8
通讯作者：
Saif LJ
中科院分区：
文献类型：
--
作者：
Vlasova AN;Kandasamy S;Chattha KS;Rajashekara G;Saif LJ
乳杆菌属和双歧杆菌属的不同益生菌菌株具有显著且广泛认可的健康促进和免疫调节特性。它们还为预防和治疗各种感染性、过敏性和炎症性疾病提供了负担得起的手段，如许多人类和动物研究所证明的。尽管有充分的证据表明这些益生菌对轮状病毒（RV）感染和疾病具有保护作用，但这种保护的精确免疫机制在很大程度上仍不确定，因为在人类中可能进行的机制研究有限，并且在大多数动物模型中进行了研究。此外，虽然大多数人类临床益生菌试验使用相同的菌株、统一的剂量、益生菌治疗方案和相似的宿主年龄进行了良好的标准化，但动物研究通常缺乏标准化，具有可变的实验设计，以及实验变量或观察参数的不统一和有时有限的选择。本文综述了不同的益生菌菌株的乳酸杆菌和双歧杆菌的选择数据，并总结了他们的免疫调节特性和相关的保护对RV疾病在不同的宿主物种，包括新生儿的知识。
Different probiotic strains of Lactobacillus and Bifidobacterium genera possess significant and widely acknowledged health-promoting and immunomodulatory properties. They also provide an affordable means for prevention and treatment of various infectious, allergic and inflammatory conditions as demonstrated in numerous human and animal studies. Despite the ample evidence of protective effects of these probiotics against rotavirus (RV) infection and disease, the precise immune mechanisms of this protection remain largely undefined, because of limited mechanistic research possible in humans and investigated in the majority of animal models. Additionally, while most human clinical probiotic trials are well-standardized using the same strains, uniform dosages, regimens of the probiotic treatments and similar host age, animal studies often lack standardization, have variable experimental designs, and non-uniform and sometime limited selection of experimental variables or observational parameters. This review presents selected data on different probiotic strains of lactobacilli and bifidobacteria and summarizes the knowledge of their immunomodulatory properties and the associated protection against RV disease in diverse host species including neonates.