Discovery of new polymorphs of the tuberculosis drug isoniazid
Discovery of new polymorphs of the tuberculosis drug isoniazid
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DOI：
10.1039/d0ce00440e
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发表时间：
2020-04
期刊：
影响因子：
3.1
通讯作者：
Keke Zhang;Noalle Fellah;A. Shtukenberg;Xiao-yan Fu;C. Hu;M. Ward
中科院分区：
文献类型：
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作者：
Keke Zhang;Noalle Fellah;A. Shtukenberg;Xiao-yan Fu;C. Hu;M. Ward
结核病药物异烟肼的两种新的亚稳态多晶型物，被认为是单晶型物60年，使用熔融结晶和纳米级限制被发现。通过光学显微镜、拉曼光谱和X-射线粉末衍射，这两种新形式很容易与已知形式区分开来。一个新的多晶型之一，获得了单晶结构。
Two new metastable polymorphs of the tuberculosis drug isoniazid, considered monomorphic for sixty years, were discovered using melt crystallization and nanoscale confinement. The two new forms are readily distinguished from the known form by optical microscopy, Raman spectroscopy and X-ray powder diffraction. A single crystal structure was obtained for one of the new polymorphs.