Autophagy and the Kidney: Implications for Ischemia-Reperfusion Injury and Therapy
Autophagy and the Kidney: Implications for Ischemia-Reperfusion Injury and Therapy
复制标题
DOI：
10.1053/j.ajkd.2015.05.021
复制
发表时间：
2015-10-01
影响因子：
13.2
通讯作者：
Jochmans, Ina
中科院分区：
文献类型：
--
作者：
Decuypere, Jean-Paul;Ceulemans, Laurens J.;Jochmans, Ina
自噬是一种进化上保守的细胞内溶酶体依赖的分解代谢过程，是肾脏病理性应激条件下细胞稳态和存活的重要机制，如缺血再灌注损伤（IRI）。然而，刺激自噬已被描述为改善和加剧肾脏中的IRI。我们总结了目前对肾IRI自噬的理解，并讨论了这些矛盾结果的可能原因。此外，我们假设自噬在肾IRI中起双重作用，具有保护和有害特性，这取决于缺血期的持续时间和IRI过程的阶段。最后，我们讨论了目前使用的利尿剂和免疫抑制药物对自噬的影响，强调需要澄清自噬在肾IRI中令人困惑的作用。(C)2015年，美国国家肾脏基金会（National Kidney Foundation，Inc.）
Autophagy, an evolutionary conserved intracellular lysosome-dependent catabolic process, is an important mechanism for cellular homeostasis and survival during pathologic stress conditions in the kidney, such as ischemia-reperfusion injury (IRI). However, stimulation of autophagy has been described to both improve and exacerbate IRI in the kidney. We summarize the current understanding of autophagy in renal IRI and discuss possible reasons for these contradictory findings. Furthermore, we hypothesize that autophagy plays a dual role in renal IRI, having both protective and detrimental properties, depending on the duration of the ischemic period and the phase of the IRI process. Finally, we discuss the influence of currently used diuretics and immunosuppressive drugs on autophagy, underscoring the need to clarify the puzzling role of autophagy in renal IRI. (C) 2015 by the National Kidney Foundation, Inc.