Organizing Principles of Human Cortical Development-Thickness and Area from 4 to 30 Years: Insights from Comparative Primate Neuroanatomy
Organizing Principles of Human Cortical Development-Thickness and Area from 4 to 30 Years: Insights from Comparative Primate Neuroanatomy
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DOI：
10.1093/cercor/bhu214
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发表时间：
2016-01-01
期刊：
影响因子：
3.7
通讯作者：
Walhovd, Kristine B.
中科院分区：
文献类型：
--
作者：
Amlien, Inge K.;Fjell, Anders M.;Walhovd, Kristine B.
人类大脑皮层经历了一个旷日持久的、地区不同的发育过程，一直持续到成年。当比较猕猴和人类的大脑时，人类发育过程中扩展最大的皮质区域对应于差异最明显的区域。然而，目前还不清楚这种关系在多大程度上源于适用于灵长类大脑的异速生长比例定律，或者代表着独特的进化适应。此外，尚不清楚这种关系是否只适用于表面积(SA)，或者也适用于皮质厚度(CT)。在331名年龄在4岁到30岁之间的参与者中，我们计算了SA和CT的年龄函数，并检查了人类皮质发育与猕猴和人类扩张以及非人类灵长类扩张之间的对应关系。CT在4~30岁呈线性负年龄函数关系，SA在12岁前呈正年龄函数关系，但进展不大。在灵长类动物中，不同的皮质扩张与SA和CT的区域成熟有关，在高扩张和低扩张的皮质区域，年龄轨迹不同。这种关系遵循异速生长比例定律，而不是代表独特的猕猴与人类的差异：与人类发育的区域对应关系在非人类灵长类动物中的扩展与人类与猕猴之间的扩展一样大。
The human cerebral cortex undergoes a protracted, regionally heterogeneous development well into young adulthood. Cortical areas that expand the most during human development correspond to those that differ most markedly when the brains of macaque monkeys and humans are compared. However, it remains unclear to what extent this relationship derives from allometric scaling laws that apply to primate brains in general, or represents unique evolutionary adaptations. Furthermore, it is unknown whether the relationship only applies to surface area (SA), or also holds for cortical thickness (CT). In 331 participants aged 4 to 30, we calculated age functions of SA and CT, and examined the correspondence of human cortical development with macaque to human expansion, and with expansion across nonhuman primates. CT followed a linear negative age function from 4 to 30 years, while SA showed positive age functions until 12 years with little further development. Differential cortical expansion across primates was related to regional maturation of SA and CT, with age trajectories differing between high- and low-expanding cortical regions. This relationship adhered to allometric scaling laws rather than representing uniquely macaque-human differences: regional correspondence with human development was as large for expansion across nonhuman primates as between humans and macaque.