Egg consumption, serum total cholesterol concentrations and coronary heart disease incidence: Japan Public Health Center-based prospective study
Egg consumption, serum total cholesterol concentrations and coronary heart disease incidence: Japan Public Health Center-based prospective study
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DOI：
10.1017/bjn20061937
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发表时间：
2006-11
影响因子：
3.6
通讯作者：
Yasuyuki Nakamura;H. Iso;Y. Kita;H. Ueshima;K. Okada;M. Konishi;M. Inoue;S. Tsugane
中科院分区：
文献类型：
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作者：
Yasuyuki Nakamura;H. Iso;Y. Kita;H. Ueshima;K. Okada;M. Konishi;M. Inoue;S. Tsugane
通常建议限制鸡蛋消费量以降低血清胆固醇浓度，从而预防CHD。我们研究了鸡蛋摄入量和总胆固醇浓度与冠心病风险的关系。根据日本公共卫生中心前瞻性研究，从1990-4年至2001年底，共随访了90 735例受试者（队列I中19 856例男性和21 408例女性，年龄40-59岁;队列II中23 463例男性和26 008例女性，年龄40-69岁）。在36%的受试者中获得了总胆固醇。将男性和女性合并进行分析。根据鸡蛋消耗量，受试者被分为四组。在两个队列中，总胆固醇≥2200 mg/l的受试者在频繁食用鸡蛋组中的发生率较低（趋势P<0·0001）。每周食用鸡蛋<1天的受试者更有可能避免富含胆固醇的饮食。尽管总胆固醇与冠心病风险显著相关，但鸡蛋消费量与冠心病风险无关。在总胆固醇≥2400 mg/l和<1800 mg/l的受试者中，CHD的多变量风险比为2.17（95% CI 1.22，3.85;趋势P= 0.0018）。总之，更频繁地吃鸡蛋，几乎每天都吃，与中年日本男性和女性冠心病发病率的增加无关。高胆固醇血症的受试者在经常食用鸡蛋的人群中较少出现，可能是因为他们避免食用鸡蛋。
Limited egg consumption is often recommended to reduce serum cholesterol concentration for the prevention of CHD. We examined the association of egg consumption and total cholesterol concentration with the risk of CHD. A total of 90 735 subjects (19 856 men and 21 408 women, aged 40–59 years in cohort I; 23 463 men and 26 008 women, aged 40–69 years in cohort II) were followed from 1990–4 to the end of 2001 under the Japan Public Health Center-based prospective study. Total cholesterol was obtained in 36 % of the subjects. Men and women were combined for the analyses. The subjects were categorised into four groups according to egg consumption. Subjects with total cholesterol ≥2200 mg/l were less frequent in frequent egg consumption groups in both cohorts (trend P<0·0001). Subjects with <1 d/week of egg consumption were more likely to avoid a cholesterol-rich diet. Egg consumption was not associated with the risk of CHD, although total cholesterol was significantly related to the risk of CHD. The multivariate hazard ratio of CHD in subjects with total cholesterol ≥2400 v. <1800 mg/l was 2·17 (95 % CI 1·22, 3·85; trend P=0·0018). In conclusion, eating eggs more frequently, up to almost daily, was not associated with an increase in CHD incidence for middle-aged Japanese men and women. Subjects with hypercholesterolaemia were less frequently in frequent egg consumption groups, probably because they avoided eating eggs.