CHROMATIN MULTIPROTEIN COMPLEXES INVOLVED IN THE MAINTENANCE OF TRANSCRIPTION PATTERNS
CHROMATIN MULTIPROTEIN COMPLEXES INVOLVED IN THE MAINTENANCE OF TRANSCRIPTION PATTERNS
复制标题
DOI：
10.1016/0959-437x(95)80005-0
复制
发表时间：
1995-04-01
影响因子：
4
通讯作者：
PARO, R
中科院分区：
文献类型：
--
作者：
ORLANDO, V;PARO, R
在果蝇中，发育过程中基因表达活性和非活性模式的维持涉及两个遗传复杂系统的活性。对显然在大型多蛋白复合物中起作用的成分进行分子分析，使我们对染色质高级结构在基因调控和核组织中的作用的理解取得了实质性进展。多梳族因子在需要稳定且遗传性失活的基因上诱导异染色质样结构。三胸组因子的作用是抵消这些受抑制的染色质结构域，从而使基因能够接触到激活因子。
In Drosophila, the maintenance of active and inactive patterns of gene expression during development involves the activity of two genetically complex systems. Molecular analysis of the components, apparently acting in large multiprotein complexes, has allowed a substantial advancement in our understanding of the role of chromatin higher order structures in gene regulation and nuclear organization. The Polycomb-group factors induce heterochromatin-like structures on genes that need to be stably and heritably inactivated. The role of the trithorax-group factors is to counteract these repressed chromatin domains and thus to render the genes accessible to activating factors.