Methadone maintenance vs. methadone taper during pregnancy: Maternal and neonatal outcomes
Methadone maintenance vs. methadone taper during pregnancy: Maternal and neonatal outcomes
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DOI：
10.1080/10550490802266276
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发表时间：
2008-01-01
影响因子：
3.7
通讯作者：
Tuten, Michelle
中科院分区：
文献类型：
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作者：
Jones, Hendree E.;O'Grady, Kevin E.;Tuten, Michelle
本研究比较了五组参与者：单独接受三天美沙酮辅助戒断（MAW） （n = 67），三天美沙酮辅助戒断后美沙酮维持（MM） （n = 8），单独接受七天美沙酮辅助戒断（n = 28），七天美沙酮辅助戒断后美沙酮维持（MM） （n = 20），或1995-2001年在城市药物治疗中心登记的连续MM样本（n = 52）。平均而言，三个MM组的患者接受治疗的时间更长，产科就诊次数更多，在项目医院分娩的次数也比单独两个MAW组的患者多。鉴于孕产妇MAW预后不佳，美沙酮维持应被视为阿片类药物依赖孕妇的主要治疗方法。
This study compared five groups of participants: those receiving either three-day methadone-assisted withdrawal (MAW) alone (n = 67), three-day MAW followed by methadone maintenance (MM) (n = 8), seven-day MAW alone (n = 28), seven-day MAW followed by MM (n = 20), or a continuous MM sample (n = 52) enrolled between 1995-2001 in an urban drug treatment center. On average, patients in the three MM groups remained in treatment longer, attended more obstetrical visits, and more often delivered at the program hospital than patients in the two MAW alone groups. Given the poor maternal MAW outcomes, methadone maintenance should be considered as the primary treatment approach for opioid-dependent pregnant women.