Associative Learning, Acquired Equivalence, and Flexible Generalization of Knowledge in Mild Alzheimer Disease
Associative Learning, Acquired Equivalence, and Flexible Generalization of Knowledge in Mild Alzheimer Disease
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DOI：
10.1097/wnn.0b013e318192ccf0
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发表时间：
2009-06-01
影响因子：
1.4
通讯作者：
Keri, Szabolcs
中科院分区：
文献类型：
--
作者：
Bodi, Nikoletta;Csibri, Eva;Keri, Szabolcs
背景：获得性等价是指先前训练将两个刺激视为等价物，从而增加它们之间的泛化的现象。以往的研究表明，海马复合体可能在获得性等价联想学习中发挥重要作用。在这项研究中，我们测试了获得性等效学习是轻度阿尔茨海默病（AD）敏感标志的可能性。方法：在联想学习测试中，前刺激是卡通面孔，后刺激是不同颜色的卡通鱼。每个卡通人物都有一些宠物鱼，任务是利用每次决定后提供的反馈来学习这些脸鱼的关联。在转移阶段，知识面鱼对被推广到新的association.Results：AD患者表现出轻度损害的培训阶段，而他们的收购等价性测试深刻受损。关联知识不能被转移到一个更灵活的retrievalcondition.Conclusions：这些结果表明，获得性等效学习是专门受损的早期AD，这可能表明海马复合体的病理。
Background: Acquired equivalence is a phenomenon in which prior training to treat 2 stimuli as equivalent increases generalization between them. Previous studies demonstrated that the hippocampal complex might play an important role in acquired equivalence associative learning. In this study, we tested the possibility that acquired equivalence learning is a sensitive marker of mild Alzheimer disease (AD).Methods: In the associative learning test, antecedent stimuli were cartoon faces and consequent Stimuli were different colored cartoon fishes. Each cartoon character had some pet fish and the task was to learn these face-fish associations using feedback provided after each decision. In the transfer phase, knowledge about face-fish pairs had to be generalized to new associations.Results: AD patients exhibited mild impairments in the training phase, whereas they were profoundly impaired on the acquired equivalence test. Associative knowledge could not be transferred to a more flexible retrieval condition.Conclusions: These results suggest that acquired equivalence learning is specifically impaired in early AD, which may indicate the pathology of the hippocampal complex.