Lung function studies. VIII. Analysis of alveolar ventilation by pulmonary N2 clearance curves.
Lung function studies. VIII. Analysis of alveolar ventilation by pulmonary N2 clearance curves.
复制标题
肺功能研究。
DOI：
10.1172/jci102575
复制
发表时间：
1952
期刊：
影响因子：
--
通讯作者：
S. Kety
中科院分区：
文献类型：
--
作者：
W. S. Fowler;E. Cornish;S. Kety
肺功能的综合分析必须包括肺通气、弥散和循环的测量。一个准确的测量肺泡通气，独立的扩散和循环，是可取的。到目前为止，没有一种方法是完全令人满意的（3）。一种方法是通过研究肺泡气体与“外来”吸入气体（例如H2（4）、He（5-7）或纯O2（8-15））平衡的时间过程。一个主要的困难是区分扩大的呼吸死腔和不均匀的肺泡通气的影响，这两者都可以延迟平衡的完成。Lilly和Hervey开发的用于连续分析呼吸气体的N2浓度的N2计允许在从呼吸空气到不间断呼吸O2的变化期间和之后对呼出的气体进行自动逐呼吸分析。确保肺N2的逐渐消除代表了与无N2气体的平衡过程，并且可以根据肺泡通气来分析。本文介绍了从健康人和心肺疾病患者获得的肺N2清除曲线，以及用于分析这些曲线的方法，该方法产生了肺泡通气的容量和时间特性的综合图像。的
A comprehensive analysis of pulmonary fuinction must include measurements of pulmonary ventilation, diffusion, and circulation. An accurate measurement of alveolar ventilation, independent of diffusion and circulation, is desirable. To date, no method has been wholly satisfactory (3). One approach has been by study of the time course of equilibration of alveolar gas with a "foreign" inspired gas, such as H2 (4), He (5-7) or pure 02 (8-15). A principal difficulty has been to differentiate between the effects of an enlarged respiratory dead space and of uneven alveolar ventilation, both of which can retard the completion of equilibration. The development by Lilly and Hervey of the N2 meter, for continuous analysis of N2 concentration of respired gas, permits an automatic breath-by-breath analysis of gas expired during and after the change from breathing air to uninterrupted breathing of 02. The ensuring progressive elimination of pulmonary N2 represents the process of equilibration with a N2-free gas, and may be analyzed in terms of alveolar ventilation. This paper presents the pulmonary N2 clearance curves obtained from healthy persons and patients with cardiorespiratory disease, and a method for analysis of these curves which yields a comprehensive picture of the volume and time characteristics of alveolar ventilation. The