Microgravity Alters Cancer Growth and Progression
Microgravity Alters Cancer Growth and Progression
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DOI：
10.2174/1568009614666140407113633
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发表时间：
2014-01-01
影响因子：
3
通讯作者：
Singh, Rana P.
中科院分区：
文献类型：
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作者：
Jhala, Dhwani V.;Kale, Raosaheb K.;Singh, Rana P.
考虑到访问空间的研究人员的健康状况和空间旅游业的未来范围，研究重力改变情况下癌症的发生、生长和发展过程至关重要。微重力对人体各种细胞的影响不同;然而，这种影响的机制尚未完全了解。因此，探索各种生理和生化过程，特别是那些可以影响癌变过程的过程是非常必要的。如果从太空返回地球后，生理或生化过程的变化不能恢复正常，则可能导致生命周期中的各种畸变和形态变化。这种变化可能导致包括癌症在内的病理状况。例如，观察到微重力会抑制免疫细胞的活性，这本身会增加癌症发展的风险。微重力如何影响决定生理和生物反应的细胞和分子事件，人们知之甚少。在微重力暴露期间，表观遗传特征也有可能发生变化，这一点尚未探讨。在此，我们回顾了微重力对相关分子和生物学过程的影响，以及它如何影响癌症的发展过程。在这方面，我们还强调了需要更多关注的研究领域，以弥合对这种生物过程的理解上的差距。
Study of the process of cancer initiation, growth and progression in altered gravity is of utmost importance considering the health status of researchers visiting in space and future scope of space tourism. Microgravity affects various cells in the body differently; however, the mechanisms of such effects are not understood completely. Therefore, it is imperative to explore various physiological and biochemical processes, particularly those which can influence the process of carcinogenesis. If the changes in physiological or biochemical processes do not revert back to normalcy even after returning from the space to earth, it may lead to various aberrations and morphological changes during the life span. Such changes could lead to pathological conditions including cancer. For example, microgravity is observed to suppress the activity of immune cells, which itself increases the risk of cancer development. It is little known how the microgravity affects cellular and molecular events that determine physiological and biological responses. There is also a possibility of changes in epigenetic signatures during microgravity exposure which remains unexplored. Herein, we have reviewed the effect of microgravity on relevant molecular and biological processes, and how it could influence the course of cancer development. In this regard, we have also highlighted the areas of research that require more attention to bridge the gap of understanding for such biological processes.