The montreal cognitive assessment, MoCA:: A brief screening tool for mild cognitive impairment
The montreal cognitive assessment, MoCA:: A brief screening tool for mild cognitive impairment
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DOI：
10.1111/j.1532-5415.2005.53221.x
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发表时间：
2005-04-01
影响因子：
6.3
通讯作者：
Chertkow, H
中科院分区：
文献类型：
--
作者：
Nasreddine, ZS;Phillips, NA;Chertkow, H
目的：开发一个10分钟的认知筛查工具（Montreal Cognitive Assessment，莫卡）来帮助一线医生检测轻度认知障碍（MCI），MCI是一种经常发展为痴呆的临床状态。设计：验证研究。地点：社区诊所和学术中心。参与者：94例患者符合MCI临床标准，并得到心理测量指标的支持，93例轻度阿尔茨海默病（AD）患者（简易精神状态检查（MMSE）评分>= 17）和90名健康老年人对照（NC）。对所有参与者进行莫卡和MMSE，并评估两种测量方法检测MCI和轻度AD的灵敏度和特异性。使用截止分数26，MMSE检测MCI的灵敏度为18%，而莫卡检测到90%的MCI受试者。在轻度AD组，MMSE的敏感性为78%，而莫卡检测到100%。MMSE和莫卡的特异性都很好（分别为100%和87%）。结论：MCI作为一个实体正在发展，有些争议。莫卡是一种简单的认知筛查工具，具有高灵敏度和特异性，用于检测MCI，目前在MMSE正常范围内的患者中进行了概念化。
OBJECTIVES: To develop a 10-minute cognitive screening tool (Montreal Cognitive Assessment, MoCA) to assist first-line physicians in detection of mild cognitive impairment (MCI), a clinical state that often progresses to dementia.DESIGN: Validation study.SETTING: A community clinic and an academic center.PARTICIPANTS: Ninety-four patients meeting MCI clinical criteria supported by psychometric measures, 93 patients with mild Alzheimer's disease (AD) (Mini-Mental State Examination (MMSE) score >= 17), and 90 healthy elderly controls (NC).MEASUREMENTS: The MoCA and MMSE were administered to all participants, and sensitivity and specificity of both measures were assessed for detection of MCI and mild AD.RESULTS: Using a cutoff score 26, the MMSE had a sensitivity of 18% to detect MCI, whereas the MoCA detected 90% of MCI subjects. In the mild AD group, the MMSE had a sensitivity of 78%, whereas the MoCA detected 100%. Specificity was excellent for both MMSE and MoCA (100% and 87%, respectively).CONCLUSION: MCI as an entity is evolving and somewhat controversial. The MoCA is a brief cognitive screening tool with high sensitivity and specificity for detecting MCI as currently conceptualized in patients performing in the normal range on the MMSE.