Pd(II)-Catalyzed C-H Activation/Aryl-Aryl Coupling of Phenol Esters
Pd(II)-Catalyzed C-H Activation/Aryl-Aryl Coupling of Phenol Esters
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Pd(II) 催化苯酚酯的 C-H 活化/芳基-芳基偶联
DOI：
10.1021/ja909818n
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发表时间：
2010-01-20
影响因子：
15
通讯作者：
Liu, Lei
中科院分区：
文献类型：
--
作者：
Xiao, Bin;Fu, Yao;Liu, Lei
虽然含氮基团导向的环钯化反应已经是众所周知的，但通过仅含氧基团与钯的配位促进的Pd（II）插入C-H键中仍然相当罕见。在本研究中，第一个环钯络合物形成从一个简单的苯酚酯，其特征在于通过X-射线晶体学。建立了一种对空气和水分不敏感的酚酯邻位C-H活化/芳基-芳基偶联的方法。该反应的效用被证明用于合成有用的苯酚衍生物。
Although nitrogen-containing group-directed cyclopalladation reactions have been well-known, Pd(II) insertion into C-H bonds promoted by coordination of an oxygen-only group to the palladium remains rather rare. In the present study, the first cyclopalladation complex formed from a simple phenol ester was characterized by X-ray crystallography. A promising protocol for the ortho C-H activation/aryl-aryl Coupling of phenol esters that was not sensitive to moisture or air was then established. The utility of the reaction was demonstrated for the synthesis of useful phenol derivatives.