A further evaluation of decision-making under risk and under ambiguity in schizophrenia
A further evaluation of decision-making under risk and under ambiguity in schizophrenia
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DOI：
10.1007/s00406-012-0330-y
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发表时间：
2013-04-01
影响因子：
4.7
通讯作者：
Raffard, Stephane
中科院分区：
文献类型：
--
作者：
Fond, Guillaume;Bayard, Sophie;Raffard, Stephane
异常决策是理解精神分裂症某些行为障碍的关键概念。然而，精神分裂症患者是否在实验设计上表现出盈利决策障碍仍然存在争议：（1）评估大样本精神分裂症患者在模糊和风险条件下的决策范式的表现;（2）研究临床变量对精神分裂症患者决策表现的影响。采用爱荷华州赌博任务（IGT）和骰子游戏任务（GDT）分别对63例精神分裂症患者和67例健康对照者在模糊和风险条件下的决策进行了评定。此外，临床变量（例如，精神分裂症症状、自我报告的抑郁和冲动）在同一天使用适当的问卷进行评估。报告了药物治疗。精神分裂症患者在IGT和GDT任务上的表现都受损。决策任务表现与临床变量之间没有相关性，GDT的低增益与精神分裂症的执行功能障碍有关。这些发现证明，精神分裂症患者在模糊和风险下的决策中都表现出障碍。
Abnormal decision-making has been described as a key-concept to understand some behavioral disturbances in schizophrenia. However, whether schizophrenia patients display impairments in profitable decision-making on experimental designs is still controversial (1) to assess performance on decision-making paradigms under ambiguity and under risk conditions in a large sample of schizophrenia patients and (2) to study the impact of clinical variables on decision-making performance in schizophrenia. The Iowa gambling task (IGT) and the game of dice task (GDT) were administered to assess, respectively, decision-making under ambiguity and under risk in 63 schizophrenia patients and 67 healthy controls. In addition, clinical variables (e.g., schizophrenic symptoms, self-reported depression, and impulsivity) were evaluated using appropriate questionnaires the same day. Pharmacological treatments were reported. Schizophrenia patients had impaired performances on both IGT and GDT tasks. No correlation between the decision-making tasks performance and clinical variables was found. Lower gains on the GDT were associated with executive dysfunctioning in schizophrenia. These findings give evidence that schizophrenia patients display impairments in both decision-making under ambiguity and under risk.