Initial ratings of different types of e-cigarettes and relationships between product appeal and nicotine delivery
Initial ratings of different types of e-cigarettes and relationships between product appeal and nicotine delivery
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DOI：
10.1007/s00213-017-4826-z
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发表时间：
2018-04-01
影响因子：
3.4
通讯作者：
McRobbie, Hayden
中科院分区：
文献类型：
--
作者：
Hajek, Peter;Przulj, Dunja;McRobbie, Hayden
人们对电子烟（EC）的特征知之甚少，这些特征促进或阻碍了从吸烟到vaping的转变。我们测试了八个品牌的EC，以确定尼古丁释放和其他产品特性如何影响用户的最初反应。十五名vapers在一夜之间戒烟和vaping后测试了每种产品。在每次会议上，参与者的vaped即兴5分钟。血液样本在基线和开始vaping后2，4，6，8，10和30分钟。参与者根据一系列特征对产品进行评级。测试的产品包括六个“类似香烟”和两个可重复填充的产品，一个带有可变电压。我们还测试了参与者自己的EC。所有产品都显着降低了吸烟的冲动。可再填充产品提供更多的尼古丁，并在缓解烟瘾、主观尼古丁释放、喉咙刺激和蒸汽产生方面获得了普遍的上级评级，但在总体评级中，它们与一种类似香烟的Blu一样。参与者对低尼古丁输送产品的吸烟量更大。参与者对来自不同EC的尼古丁递送的估计与“喉咙痛”密切相关。尼古丁释放在最初的产品评级中不如吸阻、烟嘴舒适度和减少吸烟欲望的效果重要。所有EC产品都减少了吸烟欲望。可重复充装的产品通常比尼古丁含量相似的“香烟”得到更好的评价。尼古丁释放的感知由咽喉感觉引导。较低的尼古丁释放与更频繁的吸烟有关。EC产品的第一印象是由感官信号引导的，而不是尼古丁传递。
Little is known about features of e-cigarettes (EC) that facilitate or hinder the switch from smoking to vaping. We tested eight brands of EC to determine how nicotine delivery and other product characteristics influence user's initial reactions.Fifteen vapers tested each product after overnight abstinence from both smoking and vaping. At each session, participant's vaped ad lib for 5 min. Blood samples were taken at baseline and at 2, 4, 6, 8, 10 and 30 min after starting vaping. Participants rated the products on a range of characteristics. The products tested included six 'cig-a-like' and two refillable products, one with variable voltage. We also tested participants' own EC.All products significantly reduced urges to smoke. Refillable products delivered more nicotine and received generally superior ratings in terms of craving relief, subjective nicotine delivery, throat hit and vapour production but in overall ratings, they were joined by a cig-a-like, Blu. Participants puffed more on low nicotine delivery products. Participants' estimates of nicotine delivery from different EC were closely linked to 'throat hit'. Nicotine delivery was less important in the initial product ratings than draw resistance, mouthpiece comfort and effects on reducing urge to smoke.All EC products reduced urges to smoke. Refillable products received generally more favourable ratings than 'cig-a-likes' with similar nicotine content. Perception of nicotine delivery was guided by throat sensations. Lower nicotine delivery was associated with more frequent puffing. The first impressions of EC products are guided less by nicotine delivery than by sensory signals.