Biomechanical strategies for articular cartilage regeneration
Biomechanical strategies for articular cartilage regeneration
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DOI：
10.1114/1.1603752
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发表时间：
2003-10-01
影响因子：
3.8
通讯作者：
Athanasiou, KA
中科院分区：
文献类型：
--
作者：
Darling, EM;Athanasiou, KA
两个主要的贡献关节软骨的发展是生长因子和机械负荷。长期以来，生长因子一直被用来调节不同细胞中某些分子的分泌。tgf - β超家族，特别是bmp、CDMPs、OPs和GDFs，对骨和软骨组织的发育有显著影响。这些生长因子有助于产生细胞外基质，可以承受体内的极端负荷条件。除了生长因子外，已知机械力在体外和体内刺激细胞外蛋白质的合成，并能影响组织的整体结构。负重组织，如关节软骨，在没有机械力的情况下会萎缩，这一观察结果促使研究人员将机械刺激纳入组织工程过程。本文重点介绍了机械力在关节软骨组织工程中的重要性，以及有助于刺激承重组织形成的生长因子。(C) 2003生物医学工程学会。
Two major contributions to the development of articular cartilage are growth factors and mechanical loading. Growth factors have long been used to modulate the secretion of certain molecules from different cells. The TGF-beta superfamily, specifically the BMPs, CDMPs, OPs, and GDFs, have a dramatic effect on the development of bone and cartilage tissue. These growth factors help produce an extracellular matrix that can withstand extreme loading conditions in the body. In addition to growth factors, it is known that mechanical forces stimulate the synthesis of extracellular proteins in vitro and in vivo and can affect the tissue's overall structure. Load-bearing tissue, such as articular cartilage, will atrophy in the absence of mechanical forces, and this observation has caused researchers to incorporate mechanical stimulation into the tissue engineering process. This article focuses on the importance of mechanical forces in tissue engineering of articular cartilage and the growth factors that help stimulate the formation of load-bearing tissue. (C) 2003 Biomedical Engineering Society.