The Ringlike Structure of Macular Pigment in Age-Related Maculopathy: Results from the Muenster Aging and Retina Study (MARS)
The Ringlike Structure of Macular Pigment in Age-Related Maculopathy: Results from the Muenster Aging and Retina Study (MARS)
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DOI：
10.1167/iovs.11-7610
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发表时间：
2011-10-01
影响因子：
4.4
通讯作者：
Hense, Hans-Werner
中科院分区：
文献类型：
--
作者：
Dietzel, Martha;Zeimer, Meike;Hense, Hans-Werner
目的.黄斑色素（MP）在年龄相关性黄斑病变（ARM）中的作用仍不清楚。最近的研究已经报道了MP光密度（MPOD）的空间分布的变化，包括在MPOD曲线的斜率中的第二峰（“环”）。作者以横截面的方式研究了环状结构的存在、其决定因素及其与ARM的关系。总共有369名参与明斯特老化和视网膜研究的人使用自体荧光图像的双波长分析进行了检查。根据国际分类系统，使用数字眼底照片对ARM进行分级。在73例（19.8%）研究参与者中观察到环状结构。环的MP最大值位于距中心凹中心平均0.85度处，最小值位于距中心凹中心平均0.48度处。它们在双眼之间的一致性是非常显著的。在离中心凹0 °、0.25 °和0.5 °偏心距下测量的MPOD在有环形结构的眼中显著较低，而在1.0 °和2.0 °偏心距下测量的MPOD显著高于无环形结构的眼。环状结构在女性和从不吸烟者中明显更常见，在ARM眼中发现的频率明显低于健康眼，即使在校正影响因素后也是如此（校正比值比，0.347; 95%置信区间，0.196-0.617）。MP空间分布中的环状结构相当常见，显示出高度的双侧性，并且似乎与ARM呈负相关（Invest Ophthalmol维斯Sci. 2011;52：8016-8024）DOI：10.1167/iovs.11-7610
PURPOSE. The role of macular pigment (MP) in age-related maculopathy (ARM) is still not clearly understood. Recent studies have reported on variations in the spatial distribution of MP optical density (MPOD) including a secondary peak ("ring") in the slope of the MPOD profile. The authors investigated in a cross-sectional manner the presence of ringlike structures, their determinants, and their relationship with ARM.METHODS. In all, 369 participants of the Muenster Aging and Retina Study were examined using dual-wavelength analysis of autofluorescence images. ARM was graded using digital fundus photographs according to the International Classification System.RESULTS. A ringlike structure was observed in 73 (19.8%) study participants. The MP maximum of the ring was located on average at 0.85 degrees and the minimum at 0.48 degrees from the center of the fovea. Their concordance between pairs of eyes was highly significant. MPOD measured at eccentricities of 0 degrees, 0.25 degrees, and 0.5 degrees from the fovea was significantly lower in eyes with ringlike structure, whereas it was significantly higher at 1.0 degrees and 2.0 degrees than that in eyes without the ring. Ringlike structures were significantly more common in females and never smokers and were found significantly less often in eyes with ARM than in healthy eyes, even after adjustment for influential factors (adjusted odds ratio, 0.347; 95% confidence interval, 0.196-0.617).CONCLUSIONS. Ringlike structures in the MP spatial profile are fairly common, show a high degree of bilaterality, and appeared inversely related with ARM. (Invest Ophthalmol Vis Sci. 2011;52:8016-8024) DOI:10.1167/iovs.11-7610