Chemically Modified Surface Having a Dual-Structured Hierarchical Topography for Controlled Cell Growth
Chemically Modified Surface Having a Dual-Structured Hierarchical Topography for Controlled Cell Growth
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具有双结构分层形貌的化学修饰表面，用于控制细胞生长
DOI：
10.1021/acsami.7b06197
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发表时间：
2017
影响因子：
9.5
通讯作者：
Zhang Xiaohua
中科院分区：
文献类型：
--
作者：
Peng Lun;Zhou Shenglin;Yang Bo;Bao Meimei;Chen Gaojian;Zhang Xiaohua
本文描述了一种在聚二甲基硅氧烷（PDMS）薄膜表面制备双结构分层表面形貌的技术，该技术通过简单地复制预制图案并使PDMS薄膜起皱。为了提高PDMS膜的生物相容性，我们合成了一种生物相容性的多巴胺-糖共聚物，并利用它来修饰PDMS表面的化学特性。在该共聚物中引入多巴胺组分，由于其优异的附着力，在PDMS膜表面形成碳水化合物层。该共聚物中的碳水化合物成分增强了细胞与PDMS膜之间的相互作用。我们研究了细胞外基质的化学和地形表面特性对成纤维细胞生长的影响。多巴胺-糖共聚物涂层与分层形貌的耦合对细胞的排列产生最佳的诱导效果。
This report describes a technique for fabricating dual-structured hierarchical surface topography on the surface of polydimethylsiloxane (PDMS) films through simply replicating prefabricated patterns and wrinkling PDMS films. To enhance the biocompatibility of PDMS films, we synthesize a biocompatible dopamine-glycopolymer, which is utilized to modify the chemical feature of the PDMS surface. Dopamine component in this copolymer is introduced for the formation of a carbohydrate layer on the surface of PDMS films because of its excellent adhesion. The carbohydrate component in this copolymer enhances the interactions between cells and PDMS films. We investigate the influence of the chemical and topographical surface properties of the extracellular matrix on fibroblast cell growth. The coupling of the dopamine-glycopolymer coating and hierarchical topography produces the best induction effect on the alignment of cells.