The vestibulothalamic pathway: contribution of the ascending tract of Deiters.
The vestibulothalamic pathway: contribution of the ascending tract of Deiters.
复制标题
前庭丘脑通路：Deiters 上升束的贡献。
DOI：
10.1016/0006-8993(82)90973-8
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发表时间：
1982
期刊：
影响因子：
2.9
通讯作者：
Highstein,SM
中科院分区：
文献类型：
--
作者：
Maciewicz,R;Phipps,BS;Bry,J;Highstein,SM
用轴浆运输技术研究了猫Deiters上行束（ATD）对前庭丘脑投射的贡献。大注射HRP到丘脑中心的ventrobasal复合体和尾侧腹外侧核之间的边界区域，导致在前庭核复合体和前置核舌下（PH）的细胞的双边逆行标记。在内侧纵束（MLF）和结合臂（BC）双侧广泛损伤的动物中也进行了类似的丘脑注射。在这些情况下，HRP阳性神经元主要定位于腹外侧前庭核和相邻的上级前庭核同侧的丘脑注射，证据表明，前庭丘脑神经元在这些核可能会项目到丘脑的未受损的ATD。将[35 S]蛋氨酸注射到患有MLF和BC病变的动物的头端前庭核复合体中证实了这些发现，证明了ATD中放射性标记的顺行转运，并终止于丘脑。这些实验记录了ATD对同侧前庭丘脑投射的贡献;前庭丘脑通路（PH，Y组）的其他来源可能通过本研究中病变中破坏的投射系统传播。
Axoplasmic transport techniques were used to determine the contribution of the ascending tract of Deiters (ATD) to the vestibulothalamic projection in cats. Large injections of HRP into the thalamus centered on the border region between the ventrobasal complex and the caudal ventrolateral nucleus resulted in bilateral retrograde labeling of cells in the vestibular nuclear complex and the nucleus prepositus hypoglossi (PH). Similar thalamic injections were also made in animals with extensive bilateral lessions of the medial longitudinal fasciculus (MLF) and the brachium conjuctivum (BC). HRP-positive neurons in these cases were localized principally to the ventral lateral vestibular nucleus and adjacent superior vestibular nucleus ipsilateral to the thalamic injection, evidence that vestibulothalamic neurons in these nuclei may project to the thalamus over the unlesioned ATD. Injections of [35S]methionine into the rostral vestibular nuclear complex in animals with MLF and BC lesions comfirmed these findings, demonstrating orthograde transport of radiolabel in the ATD with termination in thalamus. These experiments document a contribution of the ATD to the ipsilateral vestibulathalamic projection; other sources of the vestibulothalamic pathway (PH, Ygroup) likely travel through projection systems destroyed in the lesions made in the present study.