Selenium Supplementation Affects Insulin Resistance and Serum hs-CRP in Patients with Type 2 Diabetes and Coronary Heart Disease
Selenium Supplementation Affects Insulin Resistance and Serum hs-CRP in Patients with Type 2 Diabetes and Coronary Heart Disease
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DOI：
10.1055/s-0035-1569276
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发表时间：
2016-04-01
影响因子：
2.2
通讯作者：
Asemi, Z.
中科院分区：
文献类型：
--
作者：
Farrokhian, A.;Bahmani, F.;Asemi, Z.
据我们所知，这项研究是第一次表明补充硒对2型糖尿病（T2 DM）和冠心病（CHD）患者代谢状态的影响。本研究旨在评价补硒对2型糖尿病合并冠心病患者代谢特征、炎症生物标志物和氧化应激的影响。这项随机、双盲、安慰剂对照试验在60例年龄40-85岁的T2 DM和CHD患者中进行。参与者被随机分为2组。A组每天补硒200 g（n=30），B组每天补安慰剂（n=30），共8周。在研究开始时和8周干预后采集空腹血液样本，以量化代谢特征。8周后，与安慰剂相比，补硒导致血清胰岛素水平显著降低（-2.2 +/- 4.6 vs. +3.6 +/-8.4 IU/ml，p=0.001），稳态评估模型-胰岛素抵抗（HOMA-IR）（-0.7 +/- 1.3 vs. +0.9 +/- 2.4，p=0.004），稳态模型评估-β细胞功能（HOMA-B）（-7.5 +/- 17.2 vs. +15.1 +/- 34.5，p=0.002）和定量胰岛素敏感性检查指数（QUICKI）显著增加（+0.01 +/- 0.03 vs. -0.01 +/- 0.03，p=0.02）。此外，补充硒的患者血清高敏C反应蛋白（hs-CRP）明显降低（-1372.3 +/- 2318.8 vs. -99.8 +/- 1453.6ng/ml，p=0.01）和血浆总抗氧化能力（TAC）浓度显著升高（+301.3 +/- 400.6 vs. -127.2 +/-428.0 mmol/l，p
To our knowledge, this study is the first indicating the effects of selenium supplementation on metabolic status of patients with type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD). This study was conducted to evaluate the effects of selenium supplementation on metabolic profiles, biomarkers of inflammation, and oxidative stress of patients with T2DM and CHD. This randomized, double-blind, placebo-controlled trial was performed among 60 patients with T2DM and CHD aged 40-85 years. Participants were randomly divided into 2 groups. Group A received 200g selenium supplements (n=30) and group B received placebo per day (n=30) for 8 weeks. Fasting blood samples were taken at the beginning of the study and after 8-week intervention to quantify metabolic profiles. After 8 weeks, compared with the placebo, selenium supplementation resulted in a significant decrease in serum insulin levels (-2.2 +/- 4.6 vs. +3.6 +/- 8.4IU/ml, p=0.001), homeostasis model of assessment-insulin resistance (HOMA-IR) (-0.7 +/- 1.3 vs. +0.9 +/- 2.4, p=0.004), homeostatic model assessment-beta cell function (HOMA-B) (-7.5 +/- 17.2 vs. +15.1 +/- 34.5, p=0.002) and a significant increase in quantitative insulin sensitivity check index (QUICKI) (+0.01 +/- 0.03 vs. -0.01 +/- 0.03, p=0.02). In addition, patients who received selenium supplements had a significant reduction in serum high-sensitivity C-reactive protein (hs-CRP) (-1372.3 +/- 2318.8 vs. -99.8 +/- 1453.6ng/ml, p=0.01) and a significant rise in plasma total antioxidant capacity (TAC) concentrations (+301.3 +/- 400.6 vs. -127.2 +/- 428.0mmol/l, p