Tumors of the testis and midgut in aging flies
Tumors of the testis and midgut in aging flies
复制标题
衰老果蝇的睾丸和中肠肿瘤
作者：
R. Salomon;F. Jackson
为了更好地了解果蝇衰老的病理学，我们使用标准的外科病理学技术对大约1400只年龄从一到五周的成年雄性果蝇进行了组织学筛查。我们发现，苍蝇会患上睾丸和肠道肿瘤，而且这些肿瘤的发病率随着年龄的增长而增加。在普通人群中，老龄化是肿瘤发展的最大单一风险因素。在这里，我们第一次展示了衰老也是果蝇肿瘤发展的一个风险因素。这些发现是世界上研究最深入、基因最易处理的模式生物之一，为更深入地探索衰老和肿瘤之间的关系提供了机会。
In order to better understand the pathology of aging in the fly we used standard techniques of surgical pathology to conduct a histologic screen of approximately 1400 adult male flies ranging in age from one to five weeks. We found that flies developed tumors of the testis and gut and that the incidence of these tumors increased with age. Aging is the greatest single risk factor for the development of tumors in the general human population. Here, we show for the first time that aging is also a risk factor for tumor development in flies. These findings in one of the world's best-studied and genetically tractable model organisms open up opportunities for deeper experimental exploration of the relationship between aging and neoplasia.
影响因子：
158.5
作者：
VOGELSTEIN, B;FEARON, ER;BOS, JL
通讯作者：
BOS, JL