Lesions of the dorsal hippocampal formation interfere with background but not foreground contextual fear conditioning.
Lesions of the dorsal hippocampal formation interfere with background but not foreground contextual fear conditioning.
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DOI：
10.1101/lm.1.1.34
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发表时间：
1994-05
影响因子：
2
通讯作者：
R. Phillips;Joseph E LeDoux
中科院分区：
文献类型：
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作者：
R. Phillips;Joseph E LeDoux
在三种条件范式中检查了海马病变对恐惧反应（冻结反应）对上下文刺激（静态的，连续存在的刺激）的影响：与脚印无条件的刺激（US），不受仪式的呈现，或cess的呈现，或者是US和US，在三种条件范式中进行了调节范式的前进配对。这三个程序均导致将条件冻结收集到上下文刺激中。如前所述，背侧海马病变阻止了配对程序中的上下文调节，但在未配对或单独使用的程序中并非。在配对的过程中，静态上下文提示出现在背景中，而音调CS是进入与美国关联的主要刺激。但是，在没有阶段CS的其他两个程序中，与美国的主要关联涉及静态上下文刺激，因此在前景中。我们将这些类型的上下文条件称为背景和前景上下文调节，并认为海马仅参与背景上下文条件。这些结果对理解恐惧调节和海马功能具有影响。
The effects of hippocampal lesions on the conditioning of fear responses (freezing responses) to contextual stimuli (static, continuously present stimuli) were examined in three conditioning paradigms: forward pairing of a phasic tone conditioned stimulus (CS) with a footshock unconditioned stimulus (US), unpaired presentations of the CS and US, or presentations of the US alone. All three procedures resulted in the acquisition of conditioned freezing to contextual stimuli. Lesions of the dorsal hippocampus prevented the acquisition of contextual conditioning in the Paired procedure, as reported previously, but not in the Unpaired or US Alone procedures. In the Paired procedure, static contextual cues occur in the background, with the phasic tone CS being the primary stimulus that enters into the association with the US. However, in the other two procedures, where there is no phasic CS, the primary associations with the US involve static contextual stimuli, which are therefore in the foreground. We refer to these types of contextual conditioning as background and foreground contextual conditioning, respectively, and argue that the hippocampus is only involved in background contextual conditioning. These results have implications for understanding both fear conditioning and hippocampal function.